Murai D T, Lee C C, Wallen L D, Kitterman J A
J Appl Physiol (1985). 1985 Aug;59(2):575-9. doi: 10.1152/jappl.1985.59.2.575.
The role of the peripheral chemoreceptors in the control of fetal breathing movements has not been fully defined. To determine whether denervation of the peripheral chemoreceptors affects fetal breathing movements, we studied 14 chronically catheterized fetal sheep from 120 to 138 days of gestation. In seven fetuses the chemoreceptors were denervated by bilateral section of the vagus and carotid sinus nerves; in seven others, sham operations were performed. We compared several variables during two study periods: 0-5 and 6-13 days after operation. In the denervated fetuses there were significant decreases in the incidence and amplitude of fetal breathing movements during both study periods. There were no differences between the two groups in incidence of low-voltage electrocortical activity, arterial pH and blood gas tensions, fetal heart rate, mean arterial blood pressure, or duration of survival after operation or birth weight. We conclude that denervation of the peripheral chemoreceptors decreases fetal breathing movements. These results indicate that the peripheral chemoreceptors are active during fetal life and participate in the control of fetal breathing movements.
外周化学感受器在胎儿呼吸运动控制中的作用尚未完全明确。为了确定外周化学感受器去神经支配是否会影响胎儿呼吸运动，我们研究了14只妊娠120至138天的慢性插管胎儿绵羊。在7只胎儿中，通过双侧切断迷走神经和颈动脉窦神经使化学感受器去神经支配；另外7只进行假手术。我们在两个研究阶段比较了几个变量：术后0 - 5天和6 - 13天。在去神经支配的胎儿中，两个研究阶段胎儿呼吸运动的发生率和幅度均显著降低。两组在低电压皮层电活动发生率、动脉pH值和血气张力、胎儿心率、平均动脉血压、术后存活时间或出生体重方面没有差异。我们得出结论，外周化学感受器去神经支配会减少胎儿呼吸运动。这些结果表明，外周化学感受器在胎儿期是活跃的，并参与胎儿呼吸运动的控制。
