体育活动对代谢功能障碍相关脂肪性肝病、肌肉减少症和心血管疾病的影响。
Impact of physical activities in metabolic dysfunction associated steatotic liver disease, sarcopenia, and cardiovascular disease.
作者信息
Han Eugene, Woo Sin Yung, Jeon Justin Y, Kang Eun Seok, Cha Bong-Soo, Lee Byung-Wan, Lee Yong-Ho
机构信息
Department of Internal Medicine, Keimyung University, School of Medicine, Daegu, Republic of Korea.
Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.
出版信息
Diabetes Res Clin Pract. 2025 Jun;224:112209. doi: 10.1016/j.diabres.2025.112209. Epub 2025 Apr 28.
BACKGROUND AND AIMS
There are no comprehensive studies that investigated differential effects of physical activity (PA) types on metabolic dysfunction associated steatotic liver disease (MASLD) and their associations with sarcopenia and cardiovascular disease.
METHODS
A cross-sectional analysis using data from 66,021 participants from the Korean National Health and Nutrition Examination Surveys 2007-2020. Aerobic PA (A-PA) was defined as ≥ moderate-intensity 150 min/week or high-intensity 75 min/week; Muscle strengthening PA (MS-PA) was defined as ≥ 2 days/week of muscle strength training. Multicomponent PA included A-PA and MS-PA. The atherosclerotic cardiovascular disease (ASCVD) risk was determined by the pooled ASCVD risk score.
RESULTS
The prevalence of MASLD was lower in all PA groups compared to physically inactive individuals. Among individuals with MASLD, multicomponent PA was associated with a lower ASCVD risk, compared with other groups (OR = 0.74, 95 % CI = 0.73-0.75 for A-PA; OR = 0.70, 95 % CI = 0.68-0.64 for MS-PA; OR = 0.62, 95 % CI = 0.61-0.64 for multicomponent PA). Sarcopenia risk was decreased among physically active individuals with MASLD (OR = 0.77, 95 % CI, 0.76-0.77 for A-PA; OR = 0.97, 95 % CI = 0.96-0.98 for MS-PA; OR = 0.57, 95 % CI = 0.57-0.58 for multicomponent PA).
CONCLUSIONS
Regardless of types of exercise, physically active individuals had lower risks of MASLD, sarcopenia, and ASCVD.
背景与目的
目前尚无全面的研究调查不同类型的体育活动（PA）对代谢功能障碍相关脂肪性肝病（MASLD）的不同影响及其与肌肉减少症和心血管疾病的关联。
方法
采用2007 - 2020年韩国国民健康与营养检查调查中66,021名参与者的数据进行横断面分析。有氧运动（A-PA）定义为每周至少进行150分钟中等强度运动或75分钟高强度运动；肌肉强化运动（MS-PA）定义为每周至少进行2天的肌肉力量训练。多组分运动包括A-PA和MS-PA。动脉粥样硬化性心血管疾病（ASCVD）风险通过合并的ASCVD风险评分确定。
结果
与不运动的个体相比，所有运动组的MASLD患病率均较低。在患有MASLD的个体中，与其他组相比，多组分运动与较低的ASCVD风险相关（A-PA的OR = 0.74，95%CI = 0.73 - 0.75；MS-PA的OR = 0.70，95%CI = 0.68 - 0.64；多组分运动的OR = 0.62，95%CI = 0.61 - 0.64）。患有MASLD的运动个体的肌肉减少症风险降低（A-PA的OR = 0.77，95%CI，0.76 - 0.77；MS-PA的OR = 0.97，95%CI = 0.96 - 0.98；多组分运动的OR = 0.57，95%CI = 0.57 - 0.58）。
结论
无论运动类型如何，运动个体患MASLD、肌肉减少症和ASCVD的风险较低。
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