Zhujiang Hospital of Southern Medical University, 510150, Guangzhou, Guangdong, China.
Wien Klin Wochenschr. 2024 May;136(9-10):258-266. doi: 10.1007/s00508-023-02314-0. Epub 2024 Jan 3.
To investigate the correlations between physical activity (PA) and metabolic associated fatty liver disease (MAFLD) or metabolic dysfunction-associated steatotic liver disease (MASLD) within a substantial population-based survey, and to examine the association between PA and liver fibrosis (LF).
Data from the 2017-2020 NHANES cycle were utilized in this study. PA was divided into four types: leisure-time PA (LTPA), transportation-related PA (TPA), occupational PA (OPA) and total time PA (total PA, which is composed of OPA, TPA and LTPA). Weighted logistic regression models were performed to analyze the associations between PA and MAFLD/MASLD and LF. Mediation analysis was used to explore whether LTPA completely mediated the statistically significant relationship between total PA and MAFLD/MASLD or LF.
The study encompassed a sample size of 5897 participants aged 20 years and above, among the total participants, 2568 individuals with MAFLD and 2588 individuals with MASLD. There was no statistically significant correlation observed between OPA/TPA and MAFLD/MASLD and LF; however, active LTPA demonstrated an inverse association with MAFLD/MASLD (OR: 0.548; 95% CI: 0.458, 0.656/OR: 0.543; 95% CI: 0.453, 0.650), as well as a negative correlation with significant/advanced LF (OR: 0.457; 95% CI: 0.334,0.625/OR: 0.427; 95% CI: 0.295,0.619). There was also a significant inverse association between total PA and MAFLD/MASLD or LF, but this association was carried by the difference in LTPA.
Participation in active LTPA is associated with a reduced likelihood of MAFLD/MASLD and LF, while neither OPA nor TPA can replace these effects of LTPA.
在一项大规模基于人群的调查中，研究体力活动（PA）与代谢相关脂肪性肝病（MAFLD）或代谢相关脂肪性肝损伤（MASLD）之间的相关性，并探讨 PA 与肝纤维化（LF）之间的关系。
本研究利用 2017-2020 年 NHANES 周期的数据。将 PA 分为四种类型：休闲时间 PA（LTPA）、交通相关 PA（TPA）、职业 PA（OPA）和总时间 PA（total PA，由 OPA、TPA 和 LTPA 组成）。采用加权 logistic 回归模型分析 PA 与 MAFLD/MASLD 和 LF 之间的关系。采用中介分析探讨 LTPA 是否完全介导了总 PA 与 MAFLD/MASLD 或 LF 之间具有统计学意义的关系。
本研究纳入了 5897 名年龄在 20 岁及以上的参与者，其中 2568 名患有 MAFLD，2588 名患有 MASLD。OPA/TPA 与 MAFLD/MASLD 和 LF 之间没有统计学上的相关性；然而，积极的 LTPA 与 MAFLD/MASLD 呈负相关（OR：0.548；95%CI：0.458，0.656/OR：0.543；95%CI：0.453，0.650），与显著/进展性 LF 也呈负相关（OR：0.457；95%CI：0.334，0.625/OR：0.427；95%CI：0.295，0.619）。总 PA 与 MAFLD/MASLD 或 LF 之间也存在显著的负相关，但这种相关性是由 LTPA 的差异引起的。
积极参与 LTPA 与 MAFLD/MASLD 和 LF 的发生风险降低有关，而 OPA 和 TPA 均不能替代 LTPA 的这些作用。
