病例报告：一名癫痫患者在丙戊酸盐与拉莫三嗪联合治疗中的迟发性不良反应。
Case report: late adverse reactions in an epilepsy patient on combination therapy with valproate and lamotrigine.
作者信息
Sang Hui, Zhao Liqiao, Zhang Yanhua, Wang Xiaolong, Zhang Xiaodong
机构信息
Department of Neurology, Taiyuan City Central Hospital, The Ninth Clinical Medical College of Shanxi Medical University, Taiyuan, 030001, China.
出版信息
Acta Epileptol. 2025 Apr 30;7(1):27. doi: 10.1186/s42494-025-00217-3.
BACKGROUND
Late adverse reactions associated with the combined therapy of valproate and lamotrigine are infrequently documented within the Chinese population.
CASE PRESENTATION
This case report describes a 54-year-old female patient who developed adverse reactions following long-term therapy with valproate and lamotrigine, with symptoms emerging five months after the final adjustment of her antiseizure regimen. The patient presented with symptoms of dizziness, ataxia, nystagmus, and postural tremors. Following blood drug concentration monitoring and subsequent minor dosage adjustments to the antiseizure regimen without medication withdrawal, the patient's symptoms were successfully resolved.
CONCLUSIONS
This article underscores the importance of vigilance among clinicians regarding the potential for late adverse reactions and advocates for the proactive monitoring of blood drug concentrations.
背景
丙戊酸盐与拉莫三嗪联合治疗相关的迟发性不良反应在中国人群中鲜有记录。
病例报告
本病例报告描述了一名54岁女性患者，在长期接受丙戊酸盐和拉莫三嗪治疗后出现不良反应，症状在其抗癫痫治疗方案最后一次调整五个月后出现。患者出现头晕、共济失调、眼球震颤和姿势性震颤症状。经过血药浓度监测以及随后在不停药的情况下对抗癫痫治疗方案进行小剂量调整后，患者症状成功缓解。
结论
本文强调了临床医生对迟发性不良反应可能性保持警惕的重要性，并提倡积极监测血药浓度。
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