Zhang Xiling, Pommert Nina Sophie, Meier David, Sellers Stephanie L, Seoudy Hatim, Müller Oliver J, Frank Derk, Attmann Tim, Berndt Rouven, Warnecke Gregor, Puehler Thomas, Lutter Georg
Department of Cardiac Surgery, University Hospital Schleswig-Holstein (UKSH), Kiel, Germany.
DZHK (German Centre for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, Hamburg, Germany.
Front Cardiovasc Med. 2025 Apr 16;12:1562658. doi: 10.3389/fcvm.2025.1562658. eCollection 2025.
Severe tricuspid regurgitation (TR) is a prevalent and challenging condition associated with poor survival outcomes and significant morbidity. Medical therapy alone often fails to provide adequate symptom relief, and stand-alone surgical intervention is linked to high mortality rates, making it a less favorable option unless combined with left-sided valve surgery. The advent of transcatheter tricuspid interventions has provided new therapeutic possibilities, particularly for high-risk patients who are ineligible for conventional surgery. However, many patients are still unsuited for transcatheter tricuspid repair or have only limited benefits from such procedures. In this context, Transcatheter tricuspid valve replacement (TTVR) has rapidly emerged as a promising alternative, offering the potential for more effective treatment outcomes. This review explores the latest advancements in TTVR devices, highlights key clinical findings, and discusses the challenges and limitations of this evolving strategy. Additionally, we address patient selection criteria, procedural outcomes, and future directions in the field, emphasizing the potential of TTVR to transform the management of severe TR.
严重三尖瓣反流（TR）是一种常见且具有挑战性的疾病，与生存预后不良和显著的发病率相关。单纯药物治疗往往无法充分缓解症状，而单独的外科手术干预与高死亡率相关，除非与左侧瓣膜手术联合，否则它不是一个理想的选择。经导管三尖瓣介入治疗的出现提供了新的治疗可能性，特别是对于不适合传统手术的高危患者。然而，许多患者仍然不适合经导管三尖瓣修复，或者从这些手术中获得的益处有限。在这种背景下，经导管三尖瓣置换术（TTVR）迅速成为一种有前景的替代方案，有望带来更有效的治疗结果。本综述探讨了TTVR设备的最新进展，强调了关键的临床发现，并讨论了这一不断发展的策略所面临的挑战和局限性。此外，我们还讨论了患者选择标准、手术结果以及该领域的未来方向，强调了TTVR改变严重TR治疗管理的潜力。
