Wang Yuedong, Xin Zhifei, Wu Wenbo, Hu Zhonghui, Jia Zhenghao, Zhang Chengyao, Ma Yi, Zhang Xiaopeng
Hebei Medical University, Shijiazhuang, Hebei, China.
Department of Thoracic Surgery Hebei General Hospital, Shijiazhuang, Hebei, China.
Front Oncol. 2025 Apr 16;15:1573436. doi: 10.3389/fonc.2025.1573436. eCollection 2025.
To our knowledge, this is the first reported case of coexisting esophageal schwannoma and gastric fundus gastrointestinal stromal tumor (GIST). This case report describes the diagnostic and treatment process of a patient with esophageal schwannoma who also had a concurrent gastric fundus GIST and was presented to Hebei General Hospital (Hebei, China) in October 2024. The association between the pathogenesis of the two types of submucosal gastrointestinal tumors is unclear, with limited existing evidence in the literature. The esophageal schwannoma was misdiagnosed as a leiomyoma preoperatively, which prompted us to seek new diagnostic modalities to differentiate gastrointestinal submucosal lesions (leiomyomas, GISTs, and schwannomas). Surgical resection is considered the optimal treatment for esophageal schwannoma. The patient underwent a right single-port thoracoscopic esophageal tumor resection and recovered well, subsequently being discharged smoothly from the hospital.
据我们所知，这是首例报告的食管神经鞘瘤与胃底胃肠道间质瘤（GIST）并存的病例。本病例报告描述了一名食管神经鞘瘤患者的诊断和治疗过程，该患者同时患有胃底GIST，于2024年10月就诊于河北医科大学第一医院（中国河北）。两种类型的胃肠道黏膜下肿瘤的发病机制之间的关联尚不清楚，文献中现有证据有限。该食管神经鞘瘤术前被误诊为平滑肌瘤，这促使我们寻求新的诊断方法来鉴别胃肠道黏膜下病变（平滑肌瘤、GIST和神经鞘瘤）。手术切除被认为是食管神经鞘瘤的最佳治疗方法。该患者接受了右单孔胸腔镜食管肿瘤切除术，恢复良好，随后顺利出院。
