Rong Jian, Li Yao-Yao, Wang Xin, Wang Jia-Ning, Song Mei
Department of Burns and Plastic Surgery, The 940 Hospital of Joint Logistics Support Force of Chinese People's Liberation Army, Lanzhou 730050, Gansu Province, China.
Department of Plateau Medicine, The 940 Hospital of Joint Logistics Support Force of Chinese People's Liberation Army, Lanzhou 730050, Gansu Province, China.
World J Stem Cells. 2025 Apr 26;17(4):102917. doi: 10.4252/wjsc.v17.i4.102917.
The treatment of complex wounds presents a significant clinical challenge due to the limited availability of standardized therapeutic options. Adipose-derived stem cell exosomes (ADSC-Exos) are promising for their capabilities to enhance angiogenesis, mitigate oxidative stress, modulate inflammatory pathways, support skin cell regeneration, and promote epithelialization. These exosomes deliver non-coding RNAs, including microRNAs, long non-coding RNAs, and circular RNAs, which facilitate collagen remodeling, reduce scar formation, and expedite wound healing. This study reviews the mechanisms, therapeutic roles, and challenges of non-coding RNA-loaded ADSC-Exos in wound healing and identifies critical directions for future research. It aims to provide insights for researchers into the potential mechanisms and clinical applications of ADSC-Exos non-coding RNAs in wound healing.
由于标准化治疗方案有限，复杂伤口的治疗面临重大临床挑战。脂肪来源干细胞外泌体（ADSC-Exos）因其具有促进血管生成、减轻氧化应激、调节炎症途径、支持皮肤细胞再生和促进上皮形成的能力而颇具前景。这些外泌体携带非编码RNA，包括微小RNA、长链非编码RNA和环状RNA，它们有助于胶原蛋白重塑、减少瘢痕形成并加速伤口愈合。本研究综述了负载非编码RNA的ADSC-Exos在伤口愈合中的作用机制、治疗作用和挑战，并确定了未来研究的关键方向。其目的是为研究人员提供有关ADSC-Exos非编码RNA在伤口愈合中的潜在机制和临床应用的见解。
