Qiao Yiyu, Hu Shuqian, Shen Wei, Tang Airong, Zhang Xueting, Zhang Hanqing, Min Min, Liu Yan
Department of Gastroenterology, the 5th Medical Center of PLA General Hospital, Beijing, China.
The School of Medicine, Nankai University, Nankai District, Tianjin, China.
Endosc Int Open. 2025 Apr 15;13:a25399167. doi: 10.1055/a-2539-9167. eCollection 2025.
Obesity is a global health issue. Traditional treatment modalities such as lifestyle modifications, pharmacological interventions, and bariatric surgery often present various limitations. Recently, endoscopic bariatric and metabolic therapies (EBMTs) have emerged as promising minimally invasive approaches for weight management. These therapies reduce gastric volume and energy intake, prolong gastric emptying, and regulate hormones associated with satiety. This study evaluated endoscopic gastric purse-string suturing (EGPSS), a novel endoscopic procedure designed to reduce gastric fundus volume while minimizing associated risks. We assessed its feasibility and efficacy in a porcine model in terms of histological, physiological, and metabolic outcomes. The results suggest that EGPSS offers a viable option for metabolic control.
肥胖是一个全球性的健康问题。传统的治疗方式，如生活方式改变、药物干预和减肥手术，往往存在各种局限性。最近，内镜下减肥和代谢治疗（EBMTs）已成为有前景的微创体重管理方法。这些治疗方法可减少胃容量和能量摄入，延长胃排空时间，并调节与饱腹感相关的激素。本研究评估了内镜下胃荷包缝合术（EGPSS），这是一种旨在减少胃底容积同时将相关风险降至最低的新型内镜手术。我们从组织学、生理学和代谢结果方面评估了其在猪模型中的可行性和疗效。结果表明，EGPSS为代谢控制提供了一个可行的选择。
