Kestemont Philippe, Fanian Ferial, Garcia Philippe, Grand-Vincent Anne, Benadiba Laurent, Delmar Henry, Bodokh Isaac, Brun Patrick, Braccini Frédéric, Desouches Christophe, Paris Jérôme, Guimiot Ismahane, Salomon Catherine, Trévidic Patrick
Aesthet Surg J Open Forum. 2025 Jan 28;7:ojae110. doi: 10.1093/asjof/ojae110. eCollection 2025.
Interventions to enhance lip volume and shape are common aesthetic procedures to counter signs of aging.
This study aimed to assess the efficacy of Art Filler Lips (AFL), with or without retouching, at restoring lip shape and volume, tolerability, and persistence over 18 months.
During this open-label study, AFL (≤2.0 mL) was injected into the upper, lower, and/or both red lips and borders at baseline (D0). Patients were evaluated at D21, when, if necessary, retouching was performed. Patients were evaluated at D42, D90, D180, D270, D360, D450, and D540. The primary assessment was based on evaluation at D21 using the Medicis Lip Fullness Scale (MLFS). Satisfactory volume restoration was defined as an improvement of ≥1 point vs D0. Secondary outcomes were adverse events (AEs), and investigator and patient satisfaction rates based on Global Aesthetic Improvement Scores.
Among 73 patients (97% females; 54.4 ± 10.5 years), 56% of lips were injected without any retouch. Mean MLFS scores either for upper and lower lips separately or together, significantly improved by D21 for the patients without retouching or D42 for those with (all < .0001). At D21/42, 99% of upper lips, 94% of lower lips, and 96% of both lips showed satisfactory volume restoration. This proportion declined between D21/42 and D540. The most reported immediate AEs were swelling, sensitivity, and pain and were mild to moderate, lasting for <2 weeks.
AFL is well tolerated and produces a sustained objective and subjective lip volume restoration and shape.
改善唇部体积和形状的干预措施是对抗衰老迹象的常见美容手术。
本研究旨在评估使用或不使用补打的Art Filler Lips（AFL）在18个月内恢复唇部形状和体积、耐受性及持久性的效果。
在这项开放标签研究中，基线时（D0）将AFL（≤2.0 mL）注入上唇、下唇和/或上下唇红缘及边界。在D21时对患者进行评估，必要时进行补打。在D42、D90、D180、D270、D360、D450和D540时对患者进行评估。主要评估基于使用美迪西唇部丰满度量表（MLFS）在D21时的评估。满意的体积恢复定义为与D0相比改善≥1分。次要结果是不良事件（AE），以及基于全球美学改善评分的研究者和患者满意度。
在73例患者中（97%为女性；54.4±10.5岁），56%的唇部注射后未进行任何补打。对于未补打的患者，上唇和下唇单独或合并的平均MLFS评分在D21时显著改善，对于补打的患者在D42时显著改善（均P<0.0001）。在D21/42时，99%的上唇、94%的下唇和96%的上下唇均显示满意的体积恢复。该比例在D21/42至D540之间下降。最常报告的即时AE为肿胀、敏感和疼痛，程度为轻至中度，持续时间<2周。
AFL耐受性良好，能持续实现客观和主观的唇部体积恢复及形状改善。
