Tuono Romaric De Manfouo, Simo Josué Louokdom, Biapa Nya Prosper Cabral, Tayou Claude Tagny, Pieme Constant Anatole
Faculty of Medicine and Biomedical Sciences Université de Yaoundé 1 Yaoundé Cameroon.
Higher Institute of Health Science Université des Montagnes Bangangté Cameroon.
Health Sci Rep. 2025 Apr 29;8(5):e70773. doi: 10.1002/hsr2.70773. eCollection 2025 May.
Sickle Cell Disease is a chronic inflammatory disease that could be aggravated by exposure to variable factors such as infections, hemolysis, oxidative stress and so forth. that could preciptate variable acute or end-organ manifestation. However, the degree of inflammation could vary in individuals. Thus this study evaluates the inflammatory state (hs-CRP, IL6, ferritin) of children living with SCD and the associated factors.
We conducted an analytical cross-sectional study for 03 months. The patients included were those from the Central Hospital of Yaounde and the Regional Hospital of Bafoussam in which they are regularly monitored and/or interned in the Hematology department. The exploration of inflammation was made by determining hs-CRP, IL6, and ferritin concentrations. The hematological parameters and iron profile were evaluated using standard methods. Statistical analyses of the data were carried out using the statistical software R version 4.1.1. from which logistic regression analyses according to univariate and multivariate models made it possible to identify factors associated with inflammation in patients.
Hundred and forty-nine SCD patients were included in the study. The frequency of inflammation in the population was 42.3%. Hyperferritinemia was significantly greater ( < 0.001) in patients with inflammation compared to the noninflammatory patients (96.8% and 76.7% respectively). Patients with inflammation showed a significant elevation of iron parameters ( < 0.05). In addition, ferritin and IL6 elevation were associated with inflammation during sickle cell disease, respectively (OR = 4.96; 95% CI [1.15-36.42]; = 0.056) and (OR = 6.23; 95% CI [1.43-45.96]; = 0.030).
The elevated iron in plasma is an effect of inflammation in sickle cell patients. Thus, inflammation constitutes a significant and significant factor in worsening the pathophysiology of sickle cell disease. Hence the need of controlling inflammation and iron in the latter is necessary.
镰状细胞病是一种慢性炎症性疾病，可能因接触感染、溶血、氧化应激等多种因素而加重，这些因素可能引发各种急性或终末器官表现。然而，个体的炎症程度可能有所不同。因此，本研究评估了镰状细胞病患儿的炎症状态（高敏C反应蛋白、白细胞介素6、铁蛋白）及其相关因素。
我们进行了为期3个月的分析性横断面研究。纳入的患者来自雅温得中心医院和巴富萨姆地区医院，他们在血液科定期接受监测和/或住院治疗。通过测定高敏C反应蛋白、白细胞介素6和铁蛋白浓度来探索炎症情况。使用标准方法评估血液学参数和铁代谢指标。使用统计软件R版本4.1.1对数据进行统计分析。根据单变量和多变量模型进行逻辑回归分析，从而确定与患者炎症相关的因素。
149例镰状细胞病患者纳入研究。该人群的炎症发生率为42.3%。与无炎症患者相比，炎症患者的高铁蛋白血症显著更高（<0.001）（分别为96.8%和76.7%）。炎症患者的铁参数显著升高（<0.05）。此外，在镰状细胞病期间，铁蛋白和白细胞介素6升高分别与炎症相关（比值比=4.96；95%置信区间[1.15 - 36.42]；P = 0.056）和（比值比=6.23；95%置信区间[1.43 - 45.96]；P = 0.030）。
血浆中铁升高是镰状细胞病患者炎症的一种表现。因此，炎症是加重镰状细胞病病理生理学的一个重要因素。因此，控制后者的炎症和铁是必要的。
