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小儿群体中强化Ross手术的手术结果。

Surgical outcomes of the reinforced Ross procedure in the pediatric population.

作者信息

Bojko Markian M, Bagrodia Neelesh, Wiggins Luke, Mitchell Chace, Cleveland John D, Cleveland David C, Starnes Vaughn A

机构信息

Division of Cardiac Surgery, Department of Surgery, Heart Institute, Children's Hospital of Los Angeles, Los Angeles, Calif.

出版信息

JTCVS Open. 2025 Feb 27;24:341-349. doi: 10.1016/j.xjon.2025.02.012. eCollection 2025 Apr.

Abstract

OBJECTIVE

External reinforcement of the Ross autograft is well described in adults. However, this technique is poorly studied in pediatric patients, and indications are not strictly defined. We aim to describe our institutions experience with external Ross reinforcement in pediatric patients.

METHODS

Between 2008 and 2023, 43 patients (≤18 years) underwent the Ross procedure with external Dacron graft reinforcement. Baseline characteristics, echocardiographic measurements, and postoperative outcomes were analyzed. The median [range] follow-up (years) was 2.01 [0.13-14.94] in children <13 years and 1.31 [0.05-11.57] in adolescents 13-18 years ( = .505).

RESULTS

The median age [range] was 14 years [5-18], median weight was 56 kg [19-142], and the median body surface area was 1.6 m [0.7-2.2]. A total of 39 of 43 patients had aortic insufficiency (AI) or mixed stenosis with insufficiency, and 4 of 43 had stenosis alone. The median [range] preoperative pulmonary valve diameter was 2.1 cm [1.8-2.9] and the median [range] aortic valve annulus diameter was 2.4 cm [1.2-3.7]. The most common Dacron graft size was 26 mm. The operative mortality rate was 1 of 43 (2.3%), and there were 5 of 43 (12%) unplanned cardiac reoperations in the postoperative period. At 1 month postprocedure, the median [range] peak valve gradient was 16 mm Hg [2-35] and 2 patients had moderate AI with the remainder having mild or less AI. There was one patient who required late autograft reintervention at 10 years for autograft stenosis. The 5-year Kaplan-Meier survival was 97.7% (93.3%-100.0%).

CONCLUSIONS

With careful patient selection, external Ross reinforcement can be performed in the pediatric population and achieves acceptable postoperative valve hemodynamics, survival, and freedom from reintervention.

摘要

目的

成人Ross自体肺动脉瓣移植术的体外加固技术已有详细描述。然而,该技术在儿科患者中的研究较少,其适应症也未严格界定。我们旨在描述我们机构在儿科患者中进行Ross体外加固的经验。

方法

2008年至2023年期间,43例(≤18岁)患者接受了带涤纶补片体外加固的Ross手术。分析了患者的基线特征、超声心动图测量结果和术后结局。年龄<13岁儿童的中位随访时间(年)为2.01[0.13 - 14.94],13 - 18岁青少年为1.31[0.05 - 11.57](P = 0.505)。

结果

中位年龄[范围]为14岁[5 - 18岁],中位体重为56 kg[19 - 142 kg],中位体表面积为1.6 m²[0.7 - 2.2 m²]。43例患者中,39例患有主动脉瓣关闭不全(AI)或混合性狭窄伴关闭不全,4例仅患有狭窄。术前肺动脉瓣直径的中位值[范围]为2.1 cm[1.8 - 2.9 cm],主动脉瓣环直径的中位值[范围]为2.4 cm[1.2 - 3.7 cm]。最常用的涤纶补片尺寸为26 mm。手术死亡率为43例中的1例(2.3%),术后有43例中的5例(12%)进行了非计划性心脏再次手术。术后1个月,峰值瓣膜压差的中位值[范围]为16 mmHg[2 - 35 mmHg],2例患者有中度AI,其余患者为轻度或更轻程度的AI。有1例患者在10岁时因自体肺动脉瓣狭窄需要进行后期自体肺动脉瓣再次干预。5年Kaplan - Meier生存率为97.7%(93.3% - 100.0%)。

结论

经过仔细的患者选择,Ross体外加固技术可应用于儿科患者,并能获得可接受的术后瓣膜血流动力学、生存率及避免再次干预。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b40/12039417/4cfa17b1ad2b/ga1.jpg

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