Mathuria Nilesh, Vishwanath Krithik, Fallon Blake C, Martino Antonio, Brero Giorgio, Willson Richard C, Valderrabano Miguel, Filgueira Carly S, Bouchard Richard R
Houston Methodist Heart and Vascular Center, Houston Methodist Research Institute, Houston Methodist Hospital, Houston, Texas, USA.
Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
JACC Clin Electrophysiol. 2025 May;11(5):1024-1029. doi: 10.1016/j.jacep.2025.02.031. Epub 2025 Apr 30.
Despite advancements in catheter technology, intraoperative assessment of radiofrequency ablation (RFA) lesions remains elusive. Prior ex vivo data suggest photoacoustic imaging (PAI) can provide RFA lesion characteristics, but in vivo data are lacking. PAI involves delivering near-infrared light to tissue, leading to transient acoustic waves that can be detected by clinically available ultrasound transducers, providing optically based tissue characterization at depth. Three epicardial RFA lesions were delivered in an open-chest porcine model. In vivo PAI-based measurements of RFA lesion dimensions matched (<0.7-mm error) gross pathologic assessment, yielding in vivo feasibility data of PAI to provide intraoperative RFA lesion dimensions.
尽管导管技术有所进步，但术中对射频消融（RFA）病灶的评估仍然难以实现。先前的离体数据表明，光声成像（PAI）可以提供RFA病灶特征，但缺乏体内数据。PAI包括将近红外光传输到组织中，从而产生瞬态声波，这些声波可被临床可用的超声换能器检测到，进而在深部提供基于光学的组织特征描述。在开胸猪模型中进行了三个心外膜RFA病灶的操作。基于体内PAI对RFA病灶尺寸的测量与大体病理评估相符（误差<0.7毫米），得出了PAI提供术中RFA病灶尺寸的体内可行性数据。
