Boncuk Ulaş Sena, Acar Türkan, Eryılmaz Halil Alper, Ünal Esra, Güzey Aras Yeşim, Kılıç Eren, Saçlı Hakan, Salihi Salih, Acar Bilgehan Atılgan
Independent Researcher, 59140 Dunkerque, France.
Department of Neurology, Faculty of Medicine, Sakarya University, Sakarya 54100, Turkey.
Diagnostics (Basel). 2025 Apr 8;15(8):947. doi: 10.3390/diagnostics15080947.
: Stroke remains a leading cause of morbidity and mortality worldwide, with dyslipidemia playing a crucial role in atherosclerosis and stroke development. The Atherogenic Index of Plasma (AIP), calculated as log(triglyceride/HDL), has emerged as a biomarker for atherosclerosis and cardiovascular risk. However, its relationship with stroke prognosis remains unclear. This study aimed to investigate the association between AIP and favorable clinical outcomes at three months in acute ischemic stroke patients undergoing mechanical thrombectomy. : We conducted a retrospective analysis of 222 patients who underwent mechanical thrombectomy between December 2019 and April 2023. The association between AIP and demographic variables, etiology, successful recanalization, intracerebral hemorrhage, and three-month mRS was evaluated. AIP values were compared between patients with good (mRS 0-2) and poor (mRS 3-6) clinical outcomes. : The most common comorbidity was hypertension (72.1%), followed by AF (50%). Stroke etiologies included large artery atherosclerosis (16.2%), cardioembolism (57.2%), and undetermined causes (26.6%). AIP values were significantly lower in patients with good functional outcomes. Additionally, AIP values were inversely associated with AF but positively correlated with DM and previous stroke history. No significant relationship was observed between the AIP and successful recanalization or intracerebral hemorrhage. : This study is the first to demonstrate that elevated AIP is associated with poor functional outcomes after three months in patients undergoing mechanical thrombectomy. Given its strong correlation with prognosis, the AIP may serve as a valuable biomarker for identifying high-risk patients. Future prospective studies are needed to further validate these findings and explore the potential role of the AIP in stroke management.
中风仍然是全球发病和死亡的主要原因，血脂异常在动脉粥样硬化和中风发展中起着关键作用。血浆致动脉粥样硬化指数（AIP），计算为log（甘油三酯/高密度脂蛋白），已成为动脉粥样硬化和心血管风险的生物标志物。然而，其与中风预后的关系仍不清楚。本研究旨在调查接受机械取栓术的急性缺血性中风患者中AIP与三个月时良好临床结局之间的关联。
我们对2019年12月至2023年4月期间接受机械取栓术的222例患者进行了回顾性分析。评估了AIP与人口统计学变量、病因、成功再通、脑出血和三个月改良Rankin量表（mRS）之间的关联。比较了临床结局良好（mRS 0-2）和不良（mRS 3-6）患者的AIP值。
最常见的合并症是高血压（72.1%），其次是房颤（50%）。中风病因包括大动脉粥样硬化（16.2%）、心源性栓塞（57.2%）和不明原因（26.6%）。功能结局良好的患者AIP值显著较低。此外，AIP值与房颤呈负相关，但与糖尿病和既往中风史呈正相关。未观察到AIP与成功再通或脑出血之间存在显著关系。
本研究首次表明，接受机械取栓术的患者中，AIP升高与三个月后功能结局不良相关。鉴于其与预后的强相关性，AIP可能作为识别高危患者的有价值生物标志物。未来需要进行前瞻性研究以进一步验证这些发现，并探索AIP在中风管理中的潜在作用。
