Department of Neurology, Wuxi Huishan District People's Hospital, Affiliated Huishan Hospital of Xinglin College, Nantong University, Wuxi, Jiangsu 214000, China.
Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu 210000, China.
J Stroke Cerebrovasc Dis. 2024 Nov;33(11):107993. doi: 10.1016/j.jstrokecerebrovasdis.2024.107993. Epub 2024 Sep 4.
Atherogenic index of plasma (AIP) is a newly identified as marker of lipid metabolism and glucose metabolism, showing significant predictive value in individuals with cardiovascular disease. This study aimed to explore the correlation between AIP and early neurological deterioration (END) in ischemic stroke patients after mechanical thrombectomy (MT).
Patients with anterior circulation large artery occlusive stroke who underwent MT were retrospectively enrolled from 2 stroke center in China. The AIP is a logarithmically transformed ratio of triglycerides to high-density lipoprotein cholesterol. END was defined as an increase of ≥ 4 point in National Institutes of Health Stroke Scale within 24 hours after surgery. Multivariable regression analysis and restricted cubic spline was utilized to determine the association of AIP index with risk of END.
Of 601 patients (mean age, 70.2 ± 12.1 years; 62.1 % of male) enrolled, 91 (15.1 %) experienced postoperative END. After adjustment for potential confounders, higher AIP levels were significantly associated with an increased risk of END after MT treatment (Per 1-standard deviation increase; odd ratio, 1.474; 95 % confidence interval, 1.162-1.869, P = 0.001). Similar results were confirmed when the AIP was analyzed as a categorical variable. Restricted cubic spline further demonstrated a linear relationship between AIP and risk of END (P = 0.001 for linearity).
The present study found that a higher AIP index were associated with END in acute ischemic stroke patients following MT treatment for emergent large vessel occlusion.
血浆致动脉粥样硬化指数（AIP）是一种新发现的脂质代谢和糖代谢标志物，在心血管疾病患者中具有显著的预测价值。本研究旨在探讨机械血栓切除术（MT）后缺血性脑卒中患者 AIP 与早期神经功能恶化（END）的相关性。
本研究回顾性纳入了来自中国 2 家卒中中心的前循环大动脉闭塞性卒中患者。AIP 是甘油三酯与高密度脂蛋白胆固醇的对数比值。END 定义为术后 24 小时内 NIHSS 评分增加≥4 分。多变量回归分析和限制性立方样条用于确定 AIP 指数与 END 风险的关系。
本研究共纳入 601 例患者（平均年龄 70.2±12.1 岁，62.1%为男性），其中 91 例（15.1%）发生术后 END。在调整了潜在混杂因素后，较高的 AIP 水平与 MT 治疗后 END 的风险增加显著相关（每增加 1 个标准差，比值比 1.474，95%置信区间 1.162-1.869，P=0.001）。当 AIP 作为分类变量进行分析时，也得到了类似的结果。限制性立方样条进一步证实了 AIP 与 END 风险之间的线性关系（线性关系 P=0.001）。
本研究发现，在接受 MT 治疗紧急大血管闭塞的急性缺血性脑卒中患者中，较高的 AIP 指数与 END 相关。
