Lopes Ferraz Bruna Elias Parreira, Signorini Filho Roney César, Carvalho Lucas Ribeiro Borges, Almeida Michelle Samora, Bonetti Tatiana Carvalho de Souza, Araujo Júnior Edward, Braga Antonio, Sun Sue Yazaki, Granese Roberta
Department of Obstetrics, Paulista School of Medicine, Federal University of São Paulo (EPM-UNIFESP), Sao Paulo 04023-062, Brazil.
Discipline of Oncology, Paulista School of Medicine, Federal University of São Paulo (EPM-UNIFESP), Sao Paulo 04023-062, Brazil.
Diagnostics (Basel). 2025 Apr 16;15(8):1012. doi: 10.3390/diagnostics15081012.
The aim of our study was to evaluate maternal and perinatal outcomes in pregnant women diagnosed with cancer and treated at a single referral center in Brazil. This retrospective cohort study analyzed medical records from January 2008 to December 2020. Demographic, clinical, obstetric, and tumor-related variables were assessed. Patients were divided into two groups: Group 1 ( = 28) included women diagnosed with cancer during pregnancy or up to one year postpartum, while Group 2 ( = 11) comprised those who became pregnant during cancer investigation or treatment. The most prevalent cancers were breast (G1 = 11, G2 = 3), cervical (G1 = 10, G2 = 3), and hematologic (G1 = 2, G2 = 4). Treatment modalities included surgery ( = 11), chemotherapy ( = 21), and inadvertent radiotherapy in one case. Most newborns ( = 25) were delivered at term, with one miscarriage, one fetal death, and one neonatal death reported. Thirty-two newborns were appropriate for gestational age, and thirty-seven were discharged with their mothers. Preterm delivery was indicated for obstetric reasons in 61.5% of cases. Overall survival by cancer type was 54% for breast, 70% for cervical, and 100% for hematologic cancers. The total survival rate was 70.9%. Cervical cancer was the second most common type in this cohort. Most deliveries occurred at term, and newborns were adequate for gestational age. Despite cancer treatment during pregnancy, most neonates were discharged alongside their mothers.
我们研究的目的是评估在巴西一家单一转诊中心被诊断患有癌症并接受治疗的孕妇的孕产妇和围产期结局。这项回顾性队列研究分析了2008年1月至2020年12月的医疗记录。评估了人口统计学、临床、产科和肿瘤相关变量。患者分为两组：第1组（n = 28）包括在孕期或产后一年内被诊断患有癌症的女性，而第2组（n = 11）包括在癌症调查或治疗期间怀孕的女性。最常见的癌症是乳腺癌（第1组 = 11例，第2组 = 3例）、宫颈癌（第1组 = 10例，第2组 = 3例）和血液系统癌症（第1组 = 2例，第2组 = 4例）。治疗方式包括手术（n = 11）、化疗（n = 21），还有1例意外放疗。大多数新生儿（n = 25）足月分娩，报告1例流产、1例胎儿死亡和1例新生儿死亡。32例新生儿出生时孕周合适，37例与母亲一同出院。61.5%的病例因产科原因进行了早产。按癌症类型的总生存率为乳腺癌54%、宫颈癌70%、血液系统癌症100%。总生存率为70.9%。宫颈癌是该队列中第二常见的类型。大多数分娩为足月分娩，新生儿出生时孕周合适。尽管孕期进行了癌症治疗，但大多数新生儿与母亲一同出院。
