Andersen Ulrik Ørsø, Grønlund Casper, Thomsen Sarah Line Lindskov, Philipsen Bahareh Bakhshaie, Kørvel-Hanquist Asbjørn, Homøe Preben, Thomsen Thora Grothe, Geisler Anja
Department of Otorhinolaryngology and Maxillofacial Surgery, Zealand University Hospital, Lykkebækvej 1 4600, Køge, Denmark.
Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
Eur Arch Otorhinolaryngol. 2025 May 1. doi: 10.1007/s00405-025-09435-4.
This systematic review aims to determine whether patients with obstructive sleep apnea (OSA) undergoing Ear, Nose, and Throat (ENT) surgery have an increased risk of postoperative complications.
The review followed the Preferred Reporting Items of Systematic Reviews guidelines. A comprehensive search was conducted in Medline, EMBASE, Cochrane CENTRAL, CINAHL, and Google Scholar. The search was performed and updated the on 27th of August 2024 and included all studies involving adults diagnosed with obstructive sleep apnea (OSA) undergoing ENT surgery. Studies focused on OSA-specific surgeries were excluded. The ROBINS-I tool was used to assess the risk of bias for the included studies. The primary outcome was all reported postoperative complications.
The search identified 18,487 articles, with 88 full-text articles reviewed. Three studies, encompassing 1,071 patients, were finally included. The complications reported were desaturation, postoperative hypertension, and infections. All three studies had a serious risk of bias.
This review finds an increased risk of specific complications, including desaturation, hypertension, and infection, in OSA patients undergoing ENT surgery. However, the current body of evidence is significantly limited by the small sample sizes, heterogeneity in study design, variability in diagnostic methods, and inconsistent outcome reporting across the included studies. These limitations hinder the ability to draw definitive conclusions or establish clear recommendations regarding the perioperative management of OSA patients in ENT settings, including whether routine postoperative admission is warranted. The findings emphasize the urgent need for more rigorous, high-quality research to guide clinical decision-making.
本系统评价旨在确定接受耳鼻喉科(ENT)手术的阻塞性睡眠呼吸暂停(OSA)患者术后并发症风险是否增加。
本评价遵循系统评价的首选报告项目指南。在Medline、EMBASE、Cochrane CENTRAL、CINAHL和谷歌学术中进行了全面检索。检索于2024年8月27日进行并更新,纳入所有涉及诊断为阻塞性睡眠呼吸暂停(OSA)的成人接受耳鼻喉科手术的研究。专注于OSA特定手术的研究被排除。使用ROBINS-I工具评估纳入研究的偏倚风险。主要结局是所有报告的术后并发症。
检索到18487篇文章,审查了88篇全文文章。最终纳入三项研究,共1071例患者。报告的并发症有血氧饱和度下降、术后高血压和感染。所有三项研究都有严重的偏倚风险。
本评价发现,接受耳鼻喉科手术的OSA患者发生特定并发症(包括血氧饱和度下降、高血压和感染)的风险增加。然而,目前的证据因样本量小、研究设计异质性、诊断方法的变异性以及纳入研究中结局报告的不一致而受到显著限制。这些局限性阻碍了就耳鼻喉科环境中OSA患者的围手术期管理得出明确结论或制定明确建议的能力,包括是否有必要进行常规术后住院治疗。研究结果强调迫切需要更严格、高质量的研究来指导临床决策。