Naseem Zehra, Muhammad Aun, Chatterjee Arjun, Rubio-Tapia Alberto
Department of Internal Medicine, Cleveland Clinic, Cleveland, OH.
Department of Internal Medicine, University of Mississippi Medical Center, Jackson, MS.
Cleve Clin J Med. 2025 May 1;92(5):311-319. doi: 10.3949/ccjm.92a.24072.
Alpha-gal syndrome is an emerging condition characterized by an immunoglobulin (Ig) E-mediated reaction to galactose-alpha-1,3-galactose (alpha-gal) after consumption of mammalian-derived food products. Identified in the early 2000s, the syndrome is linked to sensitization through tick bites; in the United States, the lone star tick () is the main vector. Symptoms range from pruritus and hives to severe systemic reactions like anaphylaxis, and typically occur 3 to 8 hours after eating meat. Diagnosis involves a history of consistent symptoms, positive alpha-gal IgE serology, and dietary exclusion trials. Management focuses on avoiding foods and products that contain alpha-gal and preventing tick bites.
α-半乳糖综合征是一种新出现的疾病，其特征是在食用哺乳动物源性食品后，免疫系统对半乳糖-α-1,3-半乳糖（α-半乳糖）产生免疫球蛋白（Ig）E介导的反应。该综合征于21世纪初被发现，与蜱虫叮咬致敏有关；在美国，孤星蜱（）是主要传播媒介。症状从瘙痒和荨麻疹到严重的全身反应如过敏反应不等，通常在进食肉类后3至8小时出现。诊断包括有持续症状的病史、α-半乳糖IgE血清学阳性以及饮食排除试验。治疗重点是避免食用含有α-半乳糖的食物和产品，并防止蜱虫叮咬。
