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Variants of the MRGPRX2 Gene Found in Patients With Hypersensitivity to Quinolones and Vancomycin Show Amplified and Drug-Specific Activation Responses In Vitro.

作者信息

Quan Paola Leonor, Ollé Laia, Sabaté-Bresco Marina, Guruceaga Elizabeth, Laguna José Julio, Doña Inmaculada, Muñoz-Cano Rosa, Perez-Gracia José Luis, Martín Margarita, Gastaminza Gabriel

机构信息

Department of Allergy and Clinical Immunology, Clínica Universidad de Navarra [University of Navarra Clinic], Pamplona, Spain.

RICORS Red de Enfermedades Inflamatorias [Inflammatory Disease Network], Instituto de Salud Carlos III [National Institute of Health Carlos III], Madrid, Spain.

出版信息

Clin Exp Allergy. 2025 Sep;55(9):873-876. doi: 10.1111/cea.70068. Epub 2025 May 1.

DOI:10.1111/cea.70068
PMID:40312271
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12433733/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4d9/12433733/f2a7ab525c52/CEA-55-873-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4d9/12433733/f2a7ab525c52/CEA-55-873-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4d9/12433733/f2a7ab525c52/CEA-55-873-g001.jpg

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Variants of the MRGPRX2 Gene Found in Patients With Hypersensitivity to Quinolones and Vancomycin Show Amplified and Drug-Specific Activation Responses In Vitro.在对喹诺酮类和万古霉素过敏的患者中发现的MRGPRX2基因变体在体外显示出增强的和药物特异性的激活反应。
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2
Biological screening of a unique drug library targeting MRGPRX2.针对 MRGPRX2 的独特药物库的生物筛选。
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3
MRGPRX2 gain-of-function mutation drives enhanced mast cell reactivity in chronic spontaneous urticaria.MRGPRX2功能获得性突变导致慢性自发性荨麻疹中肥大细胞反应性增强。
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Caffeine Acts as an Agonist of Siglec-6, Inhibits MRGPRX2-Triggered Mast Cell Degranulation and Anaphylactoid Reactions.咖啡因作为唾液酸结合免疫球蛋白样凝集素-6的激动剂，抑制MRGPRX2触发的肥大细胞脱颗粒和类过敏反应。
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引用本文的文献

1
The prevalence of genetic variants of the Mas-related G-protein-coupled receptor X2 in patients does not explain perioperative hypersensitivity reactions to neuromuscular blocking agents.患者中与Mas相关的G蛋白偶联受体X2基因变异的患病率并不能解释围手术期对神经肌肉阻滞剂的过敏反应。
Front Pharmacol. 2025 Sep 1;16:1655722. doi: 10.3389/fphar.2025.1655722. eCollection 2025.

本文引用的文献

1
Vancomycin Hypersensitivity: It Is Not Always What It Seems.万古霉素超敏反应：情况并非总是表面看上去那样。
J Allergy Clin Immunol Pract. 2021 Feb;9(2):913-915. doi: 10.1016/j.jaip.2020.10.040.
2
Criteria for intradermal skin testing and oral challenge in patients labeled as fluoroquinolone allergic.标记为氟喹诺酮类药物过敏患者的皮内皮肤试验和口服激发试验标准。
J Allergy Clin Immunol Pract. 2021 Feb;9(2):1024-1028.e3. doi: 10.1016/j.jaip.2020.09.017. Epub 2020 Sep 24.
3
A Rapid Allele-Specific Assay for HLA-A*32:01 to Identify Patients at Risk for Vancomycin-Induced Drug Reaction with Eosinophilia and Systemic Symptoms.
一种用于 HLA-A*32:01 的快速等位基因特异性检测方法，用于识别发生万古霉素诱导的嗜酸性粒细胞增多和全身性症状药物反应的风险患者。
J Mol Diagn. 2019 Sep;21(5):782-789. doi: 10.1016/j.jmoldx.2019.04.006. Epub 2019 May 31.
4
Mas-Related G Protein-Coupled Receptor-X2 (MRGPRX2) in Drug Hypersensitivity Reactions.Mas 相关 G 蛋白偶联受体-X2（MRGPRX2）在药物过敏反应中的作用。
Front Immunol. 2018 Dec 20;9:3027. doi: 10.3389/fimmu.2018.03027. eCollection 2018.
5
MRGPRX2-mediated mast cell response to drugs used in perioperative procedures and anaesthesia.MRGPRX2 介导的肥大细胞对围手术期和麻醉中使用的药物的反应。
Sci Rep. 2018 Aug 2;8(1):11628. doi: 10.1038/s41598-018-29965-8.
6
Update on Quinolone Allergy.喹诺酮类药物过敏的最新情况。
Curr Allergy Asthma Rep. 2017 Aug;17(8):56. doi: 10.1007/s11882-017-0725-y.
7
A single amino acid in MRGPRX2 necessary for binding and activation by pruritogens.MRGPRX2中一个对致痒原结合和激活所必需的单氨基酸。
J Allergy Clin Immunol. 2017 Dec;140(6):1726-1728. doi: 10.1016/j.jaci.2017.05.046. Epub 2017 Jul 6.
8
Immune-mediated reactions to vancomycin: A systematic case review and analysis.万古霉素的免疫介导反应：一项系统性病例回顾与分析。
Ann Allergy Asthma Immunol. 2016 Jun;116(6):544-53. doi: 10.1016/j.anai.2016.03.030. Epub 2016 May 4.
9
Identification of a mast-cell-specific receptor crucial for pseudo-allergic drug reactions.鉴定对伪过敏性药物反应至关重要的肥大细胞特异性受体。
Nature. 2015 Mar 12;519(7542):237-41. doi: 10.1038/nature14022. Epub 2014 Dec 17.