甘油三酯、血糖、腰围与非酒精性脂肪性肝病：一项系统评价与荟萃分析

Triglyceride glucose waist circumference and non alcoholic fatty liver disease: a systematic review and meta analysis.

作者信息

Xin Ziyi, Feng Lanlan, Yu Qingwen, Shi Yongmin, Tang Ting, Tong Xuhan, Hu Siqi, You Yao, Zhang Shenghui, Zhang Xingwei, Wang Mingwei, Tang Jiake

机构信息

Department of Cardiology, Hangzhou Institute of Cardiovascular Diseases, Zhejiang Key Laboratory of Medical Epigenetics, School of Basic Medical Sciences, Engineering Research Center of Mobile Health Management System&Ministry of Education, Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou, 310015, China.

Jiande First People's Hospital, Hangzhou, 311600, China.

出版信息

BMC Gastroenterol. 2025 May 1;25(1):328. doi: 10.1186/s12876-025-03888-x.

DOI:10.1186/s12876-025-03888-x

PMID:40312323

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12044922/

Abstract

BACKGROUND

Insulin resistance (IR) plays a noticeable role in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). The triglyceride glucose-waist circumference (TyG-WC) index, a novel measure for assessing IR, may hold significant predictive value for NAFLD. However, the relationship between TyG-WC and the risk of NAFLD remains elusive. To investigate this association, this comprehensive meta-analysis was conducted.

METHODS

A systematic electronic search was conducted using the PubMed, Embase, and Web of Science databases from their inception until July 2024 to identify observational studies assessing the relationship between TyG-WC and the risk of NAFLD. Joanna Briggs Institute's critical appraisal checklist was utilized to evaluate the quality of cross-sectional studies, while the Newcastle-Ottawa Scale (NOS) score was used to assess cohort studies. The principal summary outcomes included the mean difference (MD) and the corresponding 95% confidence interval (CI).

RESULTS

In total, 10 studies comprising 38,518 participants were included in this meta-analysis, of whom 37% were diagnosed with NAFLD. The analysis revealed a significant MD between NAFLD and non-NAFLD cases (MD, 137.41; [95% CI, 121.52-153.31]).

CONCLUSION

A significant MD was identified between NAFLD and non-NAFLD cases. The TyG-WC index was found to be positively correlated with the risk of NAFLD, suggesting that it may serve as a potential indicator for NAFLD.

摘要

背景

胰岛素抵抗（IR）在非酒精性脂肪性肝病（NAFLD）的发病机制中起显著作用。甘油三酯-葡萄糖-腰围（TyG-WC）指数作为一种评估IR的新指标，可能对NAFLD具有重要的预测价值。然而，TyG-WC与NAFLD风险之间的关系仍不明确。为了研究这种关联，我们进行了这项综合荟萃分析。

方法

使用PubMed、Embase和Web of Science数据库从其创建至2024年7月进行系统的电子检索，以确定评估TyG-WC与NAFLD风险之间关系的观察性研究。采用乔安娜·布里格斯研究所的批判性评价清单来评估横断面研究的质量，而纽卡斯尔-渥太华量表（NOS）评分则用于评估队列研究。主要汇总结果包括平均差（MD）和相应的95%置信区间（CI）。