血清25-羟维生素D与肌少症肥胖风险的关联：来自英国生物银行的一项纵向观察性研究

Association of serum 25-hydroxyvitamin D with sarcopenic obesity risk: a longitudinal observational study from the UK Biobank.

作者信息

Xu Qian, Bu Fan, Song Zi-Tong, Li Kuan, Fang Chen, Luo Yuan, Zhang Lei, Pei Yu-Fang

机构信息

Department of Orthopedics, Taicang Affiliated Hospital of Soochow University, Suzhou Medical College of Soochow University, Suzhou, People's Republic of China.

Department of Epidemiology and Biostatistics, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Moe Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College of Soochow University, Suzhou, People's Republic of China.

出版信息

Obesity (Silver Spring). 2025 Jun;33(6):1136-1144. doi: 10.1002/oby.24286. Epub 2025 May 1.

DOI:10.1002/oby.24286

PMID:40312976

Abstract

OBJECTIVE

This study aims to examine the association of serum 25-hydroxyvitamin D (25[OH]D) concentration with the risk of sarcopenic obesity (SO) incidence.

METHODS

We used the longitudinal observational data from the UK Biobank cohort to evaluate the association between serum 25(OH)D concentration and the risk of SO incidence (N = 46,535). Cox proportional hazards models were used to estimate the hazard ratios (HRs) and 95% CI between serum 25(OH)D concentration and risk of SO incidence by sex.

RESULTS

During the median follow-up of 8.74 (IQR 6.70-11.06) years, there were 1086 incident SO cases. After multivariable adjustment, compared with the lowest quartile group, the HRs (95% CI) for the second, third, and fourth quartile of 25(OH)D concentration in female individuals were 0.66 (95% CI: 0.53-0.82), 0.53 (95% CI: 0.41-0.67), and 0.43 (95%: 0.33-0.55), respectively (p < 0.001). Similarly, in male individuals, the HRs (95% CI) for the second, third, and fourth quartile of 25(OH)D concentration were 0.86 (95% CI: 0.66-1.10), 0.68 (95% CI: 0.56-0.92), and 0.40 (95% CI: 0.29-0.54), respectively (p <0.001). A nonlinear association between serum 25(OH)D concentration and risk of SO incidence was observed in female (p = 0.043) and male (p = 0.008) individuals using restricted cubic spline analysis.

CONCLUSIONS

Higher serum 25(OH)D concentration was significantly associated with a lower risk of SO incidence in a dose-response relationship.

摘要

目的

本研究旨在探讨血清25-羟维生素D（25[OH]D）浓度与肌少症肥胖（SO）发病风险之间的关联。

方法

我们使用英国生物银行队列的纵向观察数据来评估血清25(OH)D浓度与SO发病风险之间的关联（N = 46,535）。采用Cox比例风险模型按性别估计血清25(OH)D浓度与SO发病风险之间的风险比（HRs）和95%置信区间（CI）。

结果

在中位随访8.74（四分位间距6.70 - 11.06）年期间，有1086例SO发病病例。多变量调整后，与最低四分位组相比，女性个体中25(OH)D浓度第二、第三和第四四分位组的HRs（95%CI）分别为0.66（95%CI：0.53 - 0.82）、0.53（95%CI：0.41 - 0.67）和0.43（95%CI：0.33 - 0.55）（p < 0.001）。同样，在男性个体中，25(OH)D浓度第二、第三和第四四分位组的HRs（95%CI）分别为0.86（95%CI：0.66 - 1.10）、0.68（95%CI：0.56 - 0.92）和0.40（95%CI：0.29 - 0.54）（p < 0.001）。使用受限立方样条分析在女性（p = 0.043）和男性（p = 0.008）个体中观察到血清25(OH)D浓度与SO发病风险之间存在非线性关联。