Hamzavi Seyedeh Fatemeh, Elahi Vahed Iman, Samadi Shams Ali, Nozari Fateme, Gamzeh Latava Baroukh, Mardukhi Saman, Sabaghi Behnoosh, Hosseini Zakieh Sadat, Masoumi Shahr-E Babak Zohre, Ahrari Sahar, Keshavarzian Ali, Rahmanian Mohammad
Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Front Cardiovasc Med. 2025 Apr 17;12:1529431. doi: 10.3389/fcvm.2025.1529431. eCollection 2025.
Hypertension (HTN) is a widespread global health challenge, and its increasing prevalence is attributed to individual and environmental risk factors. Persistent organic pollutants (POPs), especially polychlorinated biphenyls (PCBs), contribute to cardiovascular risk by accumulating in fatty tissues, which leads to oxidative stress and vascular inflammation. This review and meta-analysis aimed to investigate the association between PCB exposure and hypertension.
Adhering to the PRISMA 2020 guidelines, data sources such as PubMed, Scopus, Web of Science, and Google Scholar were systematically searched up to July 2024 to find observational studies on the link between PCBs and hypertension risk. Studies were reviewed and chosen according to established inclusion and exclusion criteria, focusing on observational studies examining PCB exposure and hypertension risk. Independent reviewers conducted data extraction, and the quality of studies was evaluated using the JBI critical appraisal tool. A meta-analysis with a random-effects model was conducted to determine combined odds ratios (ORs) for hypertension linked to total PCB exposure and specific PCB types.
Of the 494 records identified, 21 studies met the inclusion criteria, comprising 5 cohort studies, 15 cross-sectional studies, and one case-control study, totaling 51,514 participants. Exposure to total PCBs correlated with an elevated risk of hypertension (OR = 1.78, 95% CI: 1.30-2.44). Dioxin-like PCBs were also associated with a heightened risk (OR = 1.54, 95% CI: 1.24-1.90), while non-dioxin-like PCBs were not significantly linked (OR = 1.16, 95% CI: 0.81-1.66). Among individual congeners, PCB-74, PCB-118, PCB-105, and PCB-153 were significantly related to higher hypertension risk.
These findings indicate a positive correlation between PCB exposure and hypertension, particularly with dioxin-like PCBs and certain PCB congeners. Additional research is necessary to clarify the mechanisms involved and to promote measures for reducing PCB exposure, particularly in high-risk populations.
https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42024595223, PROSPERO (CRD42024595223).
高血压是一项全球性的广泛健康挑战，其患病率不断上升归因于个体和环境风险因素。持久性有机污染物（POPs），尤其是多氯联苯（PCBs），通过在脂肪组织中蓄积导致氧化应激和血管炎症，从而增加心血管疾病风险。本综述和荟萃分析旨在研究多氯联苯暴露与高血压之间的关联。
遵循PRISMA 2020指南，截至2024年7月，系统检索了PubMed、Scopus、Web of Science和谷歌学术等数据源，以查找关于多氯联苯与高血压风险之间联系的观察性研究。根据既定的纳入和排除标准对研究进行审查和筛选，重点关注考察多氯联苯暴露与高血压风险的观察性研究。由独立评审员进行数据提取，并使用JBI批判性评价工具评估研究质量。采用随机效应模型进行荟萃分析，以确定与总多氯联苯暴露及特定多氯联苯类型相关的高血压合并比值比（OR）。
在检索到的494条记录中，有21项研究符合纳入标准，包括5项队列研究、15项横断面研究和1项病例对照研究，共计51514名参与者。总多氯联苯暴露与高血压风险升高相关（OR = 1.78，95%CI：1.30 - 2.44）。类二噁英多氯联苯也与风险升高相关（OR = 1.54，95%CI：1.24 - 1.90），而非类二噁英多氯联苯则无显著关联（OR = 1.16，95%CI：0.81 - 1.66）。在单个同系物中，多氯联苯-74、多氯联苯-118、多氯联苯-105和多氯联苯-153与高血压风险升高显著相关。
这些发现表明多氯联苯暴露与高血压之间存在正相关，尤其是与类二噁英多氯联苯和某些多氯联苯同系物。有必要开展进一步研究以阐明其中涉及的机制，并推动采取措施减少多氯联苯暴露，特别是在高危人群中。
https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42024595223，PROSPERO（CRD42024595223）
