Qingyu Zhang, Wenqing Jiang, Le Ma, Yanbin Hou, Pingping Miao, Chen Lin, Jiaxin Mao, Ni Dai, Dalu Yang, Kanzhen Tong, Junting Su, Zhenzhen Zhu, Liemin Ruan, Yunxin Ji
Department of Psychiatry and Behavioral Medicine, First Hospital Affiliated to Ningbo University, Ningbo, Zhejiang, China.
Department of Child and Adolescent Psychiatry, Shanghai Mental Health Center, Shanghai, China.
Front Pharmacol. 2025 Apr 17;16:1563580. doi: 10.3389/fphar.2025.1563580. eCollection 2025.
This study aims to analyze the use of sedative-hypnotic drugs among children and adolescents in a hospital setting, providing a reference for optimizing drug use.
A retrospective analysis was conducted on the prescription data of sedative-hypnotic drugs for children and adolescents aged 6-18 years from 2018 to 2023 at the outpatient department of the hospital. Data were organized using Excel and analyzed using statistical software such as SPSS, with descriptive statistics and independent samples t-tests used to analyze medication patterns across different age groups and genders.
The majority of prescriptions originated from the psychiatry department. The most common diagnoses included depressive state, anxiety state, and sleep disorders. Combination therapy with benzodiazepines and antidepressants was the most common treatment regimen. The number of prescriptions showed a yearly increasing trend, rising from 160 in 2018 to 1,583 in 2023, and the total usage also increased annually, from 30.47 g in 2018 to 260.15 g in 2023. Despite the increase in total usage, the drug usage per prescription decreased year by year. Most patients had a medication duration of less than 30 days, and the usage increased with longer medication durations. Lorazepam and zopiclone were the most frequently used drugs. The study also found that the duration of medication use was significantly longer in female patients than in males, and significantly longer in the 6-12 age group compared to the 13-18 age group.
The use of sedative-hypnotic drugs in children and adolescents has shown a yearly increasing trend, and the management of sedative-hypnotic drug use in children and adolescents should be strengthened.
本研究旨在分析医院环境中儿童和青少年镇静催眠药物的使用情况，为优化药物使用提供参考。
对该医院门诊2018年至2023年6至18岁儿童和青少年镇静催眠药物的处方数据进行回顾性分析。数据使用Excel进行整理，并使用SPSS等统计软件进行分析，采用描述性统计和独立样本t检验分析不同年龄组和性别的用药模式。
大多数处方来自精神科。最常见的诊断包括抑郁状态、焦虑状态和睡眠障碍。苯二氮䓬类药物与抗抑郁药联合治疗是最常见的治疗方案。处方数量呈逐年上升趋势，从2018年的160张增至2023年的1583张，总用量也逐年增加，从2018年的30.47克增至2023年的260.15克。尽管总用量增加，但每张处方的药物用量逐年下降。大多数患者的用药时长少于30天，且用药时长越长用量越高。劳拉西泮和佐匹克隆是最常用的药物。研究还发现，女性患者的用药时长显著长于男性，6至12岁年龄组的用药时长显著长于13至18岁年龄组。
儿童和青少年镇静催眠药物的使用呈逐年上升趋势，应加强对儿童和青少年镇静催眠药物使用的管理。
