Yao Fang, Huang Zhifeng, Chen Xueyu, Yang Chuanzhong, Li Qiuping, Lin Bingchun
The Second School of Clinical Medicine, Southern Medical University, Guangzhou, China.
Department of Neonatology, Shenzhen Maternity and Child Healthcare Hospital, Southern Medical University, Shenzhen, Guangdong Province, China.
Front Pediatr. 2025 Apr 17;13:1582881. doi: 10.3389/fped.2025.1582881. eCollection 2025.
To determine whether administering low-dose hydrocortisone early in treatment reduces the risk of bronchopulmonary dysplasia (BPD) in infants born before 26 weeks of gestation.
This retrospective case-control study compared the incidence of Grade II BPD between infants who received hydrocortisone treatment and those who did not. Propensity score matching was used to ensure comparability between the groups, with a 1:1 match ratio based on gestational age and birth weight.
A total of 66 infants were included in the study. Those who received early low-dose hydrocortisone demonstrated a significantly lower risk of Grade II BPD incidence ( = 0.024). Additionally, early administration of low-dose hydrocortisone was associated with a shorter duration of non-invasive ventilation days ( = 0.038). Multiple logistic regression analysis confirmed that hydrocortisone treatment was independently associated with a reduced risk of Grade II + BPD incidence (OR: 0.287, 95% CI: 0.084-0.980).
These findings suggest that early administration of low-dose hydrocortisone is associated with a reduced risk of Grade II BPD in extremely preterm infants born before 26 weeks of gestation.
确定在治疗早期给予低剂量氢化可的松是否能降低孕周小于26周的婴儿发生支气管肺发育不良（BPD）的风险。
这项回顾性病例对照研究比较了接受氢化可的松治疗的婴儿与未接受治疗的婴儿中II级BPD的发生率。采用倾向评分匹配法以确保两组之间具有可比性，匹配比例为1:1，匹配因素为孕周和出生体重。
共有66名婴儿纳入本研究。接受早期低剂量氢化可的松治疗的婴儿发生II级BPD的风险显著降低（P = 0.024）。此外，早期给予低剂量氢化可的松与无创通气天数缩短相关（P = 0.038）。多因素logistic回归分析证实，氢化可的松治疗与降低II级及以上BPD发生率独立相关（OR：0.287，95%CI：0.084 - 0.980）。
这些研究结果表明，对于孕周小于26周的极早产儿，早期给予低剂量氢化可的松与降低II级BPD的风险相关。
