Yang Jiaqi, Wang Yu, Liu Fangyuan, Zhang Yizhong, Han Fengjuan
Postgraduate School of Traditional Chinese Gynecology, Heilongjiang University of Traditional Chinese Medicine, Harbin, Heilongjiang 150040, P.R. China.
Department of Gynecology, The First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, Harbin, Heilongjiang 150040, P.R. China.
Int J Mol Med. 2025 Jun;55(6). doi: 10.3892/ijmm.2025.5538. Epub 2025 May 2.
Ferroptosis is a unique mode of cell death driven by iron‑dependent phospholipid peroxidation, and its mechanism primarily involves disturbances in iron metabolism, imbalances in the lipid antioxidant system and accumulation of lipid peroxides. Protein processing, modification and folding in the endoplasmic reticulum (ER) are closely related regulatory processes that determine cell function, fate and survival. The uncontrolled proliferative capacity of malignant cells generates an unfavorable microenvironment characterized by high metabolic demand, hypoxia, nutrient deprivation and acidosis, which promotes the accumulation of misfolded or unfolded proteins in the ER, leading to ER stress (ERS). Ferroptosis and ERS share common pathways in several diseases, and the two interact to affect cell survival and death. Additionally, cell death pathways are not linear signaling cascades, and different pathways of cell death may be interrelated at multiple levels. Ferroptosis and ERS in ovarian cancer (OC) have attracted increasing research interest; however, both are discussed separately regarding OC. The present review aims to summarize the associations and potential links between ferroptosis and ERS, aiming to provide research references for the development of therapeutic approaches for the management of OC.
铁死亡是一种由铁依赖性磷脂过氧化驱动的独特细胞死亡模式，其机制主要涉及铁代谢紊乱、脂质抗氧化系统失衡和脂质过氧化物积累。内质网（ER）中的蛋白质加工、修饰和折叠是密切相关的调节过程，决定着细胞的功能、命运和存活。恶性细胞不受控制的增殖能力产生了一个以高代谢需求、缺氧、营养剥夺和酸中毒为特征的不利微环境，这促进了内质网中错误折叠或未折叠蛋白质的积累，导致内质网应激（ERS）。铁死亡和内质网应激在几种疾病中具有共同途径，二者相互作用影响细胞存活和死亡。此外，细胞死亡途径并非线性信号级联，不同的细胞死亡途径可能在多个层面相互关联。卵巢癌（OC）中的铁死亡和内质网应激已引起越来越多的研究兴趣；然而，在卵巢癌方面，二者是分别进行讨论的。本综述旨在总结铁死亡和内质网应激之间的关联及潜在联系，旨在为卵巢癌治疗方法的开发提供研究参考。
