Department of Clinical Laboratory, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.
Cancer Biol Med. 2023 Oct 10;20(10):748-64. doi: 10.20892/j.issn.2095-3941.2023.0232.
The endoplasmic reticulum (ER), an organelle present in various eukaryotic cells, is responsible for intracellular protein synthesis, post-translational modification, and folding and transport, as well as the regulation of lipid and steroid metabolism and Ca homeostasis. Hypoxia, nutrient deficiency, and a low pH tumor microenvironment lead to the accumulation of misfolded or unfolded proteins in the ER, thus activating ER stress (ERS) and the unfolded protein response, and resulting in either restoration of cellular homeostasis or cell death. ERS plays a crucial role in cancer oncogenesis, progression, and response to therapies. This article reviews current studies relating ERS to ovarian cancer, the most lethal gynecologic malignancy among women globally, and discusses pharmacological agents and possible targets for therapeutic intervention.
内质网（ER）是一种存在于各种真核细胞中的细胞器，负责细胞内蛋白质的合成、翻译后修饰、折叠和运输，以及脂质和类固醇代谢和 Ca 离子平衡的调节。缺氧、营养缺乏和低 pH 值的肿瘤微环境导致内质网中错误折叠或未折叠的蛋白质积累，从而激活内质网应激（ERS）和未折叠蛋白反应，导致细胞内稳态的恢复或细胞死亡。ERS 在癌症的发生、发展和对治疗的反应中起着至关重要的作用。本文综述了 ERS 与卵巢癌的关系，卵巢癌是全球女性中最致命的妇科恶性肿瘤，并讨论了药理学制剂和可能的治疗干预靶点。
