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Lysosomal mutations inhibit lipofuscinosis of the spleen in C57BL mice.

作者信息

Ahmed F, Shire J G

出版信息

J Hered. 1985 Jul-Aug;76(4):311-2. doi: 10.1093/oxfordjournals.jhered.a110101.

DOI:10.1093/oxfordjournals.jhered.a110101
PMID:4031470
Abstract

Beige, bg, and reduced pigmentation, rp, are recessive mutations affecting lysosomal function. Homozygosity for beige prevented lipofuscinosis of the spleen in C57BL mice and its incidence was greatly reduced by homozygosity for rp. Dilute (d) homozygotes, with normal lysosomes, were susceptible to lipofuscinosis even though their melanosomes were more severely affected than those of beige mice.

摘要

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