磁共振引导激光间质热疗中脑切开术治疗药物难治性恶性疼痛。
MR-guided Laser Interstitial Thermal Therapy mesencephalotomy for medically intractable malignant pain.
作者信息
Aubignat Mickael, Constans Jean-Marc, Ouendo Martial, Arnault Jean-Philippe, Josse Claire, Desenclos Christine, Lefranc Michel
机构信息
Department of Neurology, Amiens University Hospital, Amiens, France.
Research Unit UR-4559 (LNFP), Laboratoire de Neurosciences Fonctionnelles Et Pathologies, University of Picardie Jules Verne, Amiens, France.
出版信息
Acta Neurochir (Wien). 2025 May 2;167(1):132. doi: 10.1007/s00701-025-06544-1.
Stereotactic mesencephalotomy is a neurosurgical technique designed to sever spinothalamic pain transmission pathways for medically intractable pain. This report presents the first case of Magnetic Resonance-guided Laser Interstitial Thermal Therapy (MRgLITT) mesencephalotomy for severe malignant pain due to metastatic melanoma. The procedure significantly reduced the patient's pain, with a postoperative visual analog scale (VAS) score decreasing from > 7 to < 3. No adverse effects were observed. The case underscores the potential of MRgLITT mesencephalotomy as a precise, minimally invasive option for pain management in palliative care settings.
立体定向中脑切开术是一种神经外科技术，旨在切断脊髓丘脑束疼痛传导通路，用于治疗药物难治性疼痛。本报告介绍了首例磁共振引导激光间质热疗（MRgLITT）中脑切开术治疗转移性黑色素瘤所致严重恶性疼痛的病例。该手术显著减轻了患者的疼痛，术后视觉模拟评分（VAS）从>7降至<3。未观察到不良反应。该病例强调了MRgLITT中脑切开术作为姑息治疗中疼痛管理的一种精确、微创选择的潜力。
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