Aune T M, Freeman G L, Colley D G
J Immunol. 1985 Oct;135(4):2768-71.
Chronic schistosomiasis mansoni is a helminthic infection characterized by cell-mediated anti-egg granulomatous reactions and a variety of associated immunoregulatory phenomena. Soluble immune response suppressor (SIRS) is a lymphokine produced by activated suppressor T lymphocytes in various experimental settings. This report demonstrates the presence of SIRS in the sera of mice with chronic schistosomiasis mansoni (at least 20 wk of infection), but not in the sera of mice with earlier infections. Also, cultures of isolated, intact, hepatic, egg-focused granulomas from chronically infected mice released detectable levels of SIRS. These are the immunomodulated lesions characteristic of this infection. Large, intense, unmodulated granulomas obtained from acutely infected mice did not release SIRS. There is, therefore, a strong association between the presence of SIRS in the serum, the production of SIRS by intact lesions, and the chronic, immunomodulated stage of schistosomiasis mansoni.
慢性曼氏血吸虫病是一种蠕虫感染，其特征为细胞介导的抗虫卵肉芽肿反应以及各种相关的免疫调节现象。可溶性免疫反应抑制因子（SIRS）是在各种实验环境中由活化的抑制性T淋巴细胞产生的一种淋巴因子。本报告证明，慢性曼氏血吸虫病小鼠（感染至少20周）的血清中存在SIRS，但早期感染小鼠的血清中不存在。此外，从慢性感染小鼠分离出的完整肝内虫卵聚焦肉芽肿培养物释放出可检测水平的SIRS。这些是该感染的免疫调节病变特征。从急性感染小鼠获得的大而强烈、未调节的肉芽肿不释放SIRS。因此，血清中SIRS的存在、完整病变产生SIRS与慢性曼氏血吸虫病的免疫调节阶段之间存在密切关联。
