解锁淋巴细胞激活基因3（LAG3）：泛素的意外作用。
Unlocking LAG3: Ubiquitin's unexpected role.
作者信息
Zhao Ye, Wucherpfennig Kai W
机构信息
Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Immunology, Harvard Medical School, Boston, MA 02115, USA; Department of Neurology, Brigham & Women's Hospital, Boston, MA 02115, USA.
出版信息
Cell. 2025 May 1;188(9):2307-2309. doi: 10.1016/j.cell.2025.03.030.
The inhibitory receptor LAG3 is the target of the FDA-approved mAb relatlimab, but its mechanism of signaling is not well understood. In this issue of Cell, Jiang et al. demonstrate that ubiquitination of its cytoplasmic domain is essential for the inhibitory function of LAG3. Co-expression of LAG3 and the CBL E3 ligases represents a biomarker of clinical response to LAG3 inhibition in human melanoma.
抑制性受体LAG3是美国食品药品监督管理局（FDA）批准的单克隆抗体relatlimab的靶点，但其信号传导机制尚不清楚。在本期《细胞》杂志中，蒋等人证明其胞质结构域的泛素化对于LAG3的抑制功能至关重要。LAG3与CBL E3连接酶的共表达代表了人类黑色素瘤对LAG3抑制的临床反应生物标志物。
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