El-Khodary Sherif A, Menazea A A, Abdelhamid Sayeda Abdelrazek, Khalaf Mohamed
Institute for Energy Research, Jiangsu University, 212013 Zhenjiang, PR China; Building Physics and Environment Institute, Housing & Building National Research Center (HBRC), Dokki, Giza 12311, Egypt.
Spectroscopy Department, Physics Research Institute, National Research Centre, Dokki, 12622 Giza, Egypt.
Int J Biol Macromol. 2025 Jun;311(Pt 3):143745. doi: 10.1016/j.ijbiomac.2025.143745. Epub 2025 Apr 30.
Skin wound healing is undoubtedly a complex and challenging process. Creating innovative bio-nanocomposites for skin care and wound healing/dressing applications are currently an urgent need. In this context, a mixture of chitosan (CS) and MnO nanowires (NWs), as potential wound dressing nano-film, are systematically investigated for optical, electrical, and antibacterial applications. The crystallinity of the materials was investigated through XRD, while FTIR was used to examine the interactions between the CS films and the MnO nanofiller. The resulting nanocomposite membranes exhibit superior swelling capacity than that of the pure CS membrane. Additionally, the thermal stability of the films was evaluated, demonstrating the highest stability of composite samples. The optical properties, including bandgap energies and refractive indices, can be adjusted by tuning the content of MnO. Remarkably, the refractive index dropped from 3.76 in pure CS film to 3.4 in the highest fraction of MnO (CS-4 wt% MnO). The impedance analysis was further improved for the (CS-4 wt% MnO) sample, posing lower interfacial resistance. A comprehensive investigation of the antibacterial performance of the prepared films was carried out against five bacteria types. The pure CS film exhibited mostly inhibitory effects against Gram-positive bacteria (i.e., B. subtilis, and S. aureus) between the 19 and 14 mm range, while the Gram-negative bacteria (i.e., E. coli, and P. aeruginosa) showed activity between the 19 and 20 mm range, with an effect on A. niger and C. albicans 17 and 22 mm. However, the addition of MnO has significantly increased its antimicrobial activity. Overall, the prepared CS films demonstrate great potential for multifunctional applications, including antibacterial, wound healing, and optoelectronics.
皮肤伤口愈合无疑是一个复杂且具有挑战性的过程。目前迫切需要开发用于皮肤护理和伤口愈合/敷料应用的创新型生物纳米复合材料。在此背景下，壳聚糖（CS）和MnO纳米线（NWs）的混合物作为潜在的伤口敷料纳米薄膜，被系统地研究用于光学、电学和抗菌应用。通过XRD研究了材料的结晶度，同时使用FTIR来检查CS薄膜与MnO纳米填料之间的相互作用。所得的纳米复合膜表现出比纯CS膜更高的溶胀能力。此外，还评估了薄膜的热稳定性，结果表明复合样品具有最高的稳定性。通过调整MnO的含量，可以调节包括带隙能量和折射率在内的光学性质。值得注意的是，折射率从纯CS膜中的3.76降至MnO含量最高时（CS-4 wt% MnO）的3.4。（CS-4 wt% MnO）样品的阻抗分析得到进一步改善，界面电阻更低。对制备的薄膜针对五种细菌类型的抗菌性能进行了全面研究。纯CS膜对革兰氏阳性菌（即枯草芽孢杆菌和金黄色葡萄球菌）大多表现出19至14毫米范围内的抑制作用，而革兰氏阴性菌（即大肠杆菌和铜绿假单胞菌）在19至20毫米范围内表现出活性，对黑曲霉和白色念珠菌的作用范围为17至22毫米。然而，MnO的添加显著提高了其抗菌活性。总体而言，制备的CS膜在包括抗菌、伤口愈合和光电子学等多功能应用方面显示出巨大潜力。
