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运动诱导的高钙血症与钙调节激素

Exercise-induced hypercalcemia and the calciotropic hormones.

作者信息

Aloia J F, Rasulo P, Deftos L J, Vaswani A, Yeh J K

出版信息

J Lab Clin Med. 1985 Sep;106(3):229-32.

PMID:4031628
Abstract

Sixteen healthy male volunteers exercised on a bicycle ergometer starting at 40% Vo2max and progressing at 5-minute intervals up to 75% Vo2max over a 20-minute period. Blood was drawn from an indwelling venous catheter at baseline, at 5 minutes through 20 minutes, and at 10 and 20 minutes after the exercise was ended. Significant increases (which returned toward baseline in the rest period) were observed during the exercise period in total calcium and calcium ion activity, phosphate, potassium, magnesium, albumin, and lactic acid levels. Plasma volume (based on hematocrit value) decreased during the exercise period. Serum parathyroid hormone levels decreased and calcitonin levels increased at the early period of the short-term exercise. Although hemoconcentration was of sufficient magnitude to explain the change in calcium ion activity, the increase in potassium and phosphate were caused in part by additional factors.

摘要

16名健康男性志愿者在自行车测力计上进行锻炼,从40%的最大摄氧量开始,每隔5分钟递增,在20分钟内达到75%的最大摄氧量。在基线时、5分钟至20分钟期间以及运动结束后10分钟和20分钟时,通过留置静脉导管采集血液。在运动期间观察到总钙、钙离子活性、磷酸盐、钾、镁、白蛋白和乳酸水平显著升高(在休息期恢复至基线水平)。运动期间血浆量(基于血细胞比容值)减少。短期运动早期血清甲状旁腺激素水平降低,降钙素水平升高。尽管血液浓缩程度足以解释钙离子活性的变化,但钾和磷酸盐的升高部分是由其他因素引起的。

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