Patterson R, Harris K E
J Lab Clin Med. 1985 Sep;106(3):293-7.
In continuation of studies of four rhesus monkeys infected with Ascaris suum (J Lab Clin Med 101:864-872, 1983), we report the duration of IgE-mediated skin reactivity and airway responses to Ascaris antigen from 15 weeks to longer than 2.8 years. A second group of four rhesus monkeys was infected with A. suum ova after determination of the threshold of airway reactivity to carbachol. Evaluation of these animals confirmed the initial results of the first group of animals studied in relation to induction of skin and airway reactivity to Ascaris antigen. In addition, all animals developed increased airway reactivity, demonstrated by increased reactivity to lower concentrations of carbachol. We report this as a demonstration of induced IgE-mediated antigen airway responsiveness accompanied by induction of increased airway reactivity in a primate model. The increased airway reactivity does not appear related to the induction of IgE antibody.
在对4只感染猪蛔虫的恒河猴进行研究（《实验室与临床医学杂志》101:864 - 872, 1983）的后续研究中，我们报告了IgE介导的皮肤反应性和气道对蛔虫抗原的反应持续时间，从15周直至超过2.8年。在确定气道对卡巴胆碱的反应阈值后，第二组4只恒河猴感染了猪蛔虫卵。对这些动物的评估证实了第一组研究动物关于诱导皮肤和气道对蛔虫抗原反应性的初步结果。此外，所有动物的气道反应性均增强，表现为对较低浓度卡巴胆碱的反应性增加。我们将此报告为在灵长类动物模型中诱导的IgE介导的抗原气道反应性伴有气道反应性增加的证明。气道反应性的增加似乎与IgE抗体的诱导无关。
