Beshaw Mulat Addis, Siraj Ekram Mohammed, Demass Tilahun Bizuayehu, Lakew Ayenew Molla
Department of Internal Medicine, University of Gondar, Gondar, Ethiopia
Department of Internal Medicine, Alert Comprehensive Specialized Hospital, Addis Ababa, Ethiopia.
BMJ Open. 2025 May 2;15(5):e091111. doi: 10.1136/bmjopen-2024-091111.
To assess the severity of anaemia and associated factors among drug-resistant tuberculosis (DR-TB) patients treated in DR-TB treatment-initiating centers in Addis Ababa, Ethiopia.
A retrospective cross-sectional study.
This study was conducted in Alert and St. Peters specialised hospitals, Addis Ababa, from 20 September to 15 October 2022.
Data was collected from 331 patients with DR-TB. The data was entered into Epi-Data 4.1, and SPSS version 25 was used for data cleaning and analysis. A multinomial logistic regression model was fitted after the multi-collinearity assumptions, and goodness-of-fit tests were done. The OR with 95% CI was reported for each outcome variable, taking normal haemoglobin level as a reference category. Variables with a P value of ˂0.05 were considered statistically significant.
Of the 331 patients, 51.4% had baseline anaemia, of which 5.7%, 15.7% and 29.9% had severe, moderate and mild anaemia, respectively.Patients who were urban residents (AOR: 0.06, 95% CI: 0.012, 0.32), government employees (AOR: 0.33, 95% CI: 0.001, 0.79), private job holders (AOR: 0.02, 95% CI: 0.001, 0.27), undernourished (AOR: 15.72, 95% CI: 2.46, 100.28), patients with HIV (AOR: 7.28, 95% CI: 1.627, 32.628) and farmers and students (AOR: 0.05, 95% CI: 0.004, 0.58) were significantly associated with severe anaemia.Patients who were male (AOR: 0.31, 95% CI: 0.11, 0.93), single (AOR: 0.19, 95% CI: 0.04, 0.85), daily labourer (AOR: 6.19, 95% CI: 1.27, 30.2), undernourished (AOR: 12.83, 95% CI: 4.88, 33.7) and patients with HIV (AOR: 12.74, 95% CI: 4.67, 34.75) were significantly associated with moderate anaemia. Patients with undernutrition (AOR: 3.92, 95% CI: 2.1, 7.35), HIV (AOR: 2.79, 95% CI: 1.22, 6.39) and primary and secondary education (AOR: 0.36, 95% CI: 0.17, 0.77) were significantly associated with mild anaemia.
In our study, more than 50% of patients with DR-TB had baseline anaemia, of which mild anaemia was the most common typeanaemia. Rural residents were at a higher risk of developing severe anaemia (11.5%), while the overall rate of anaemia (58.8%) was higher among urban residents.
评估在埃塞俄比亚亚的斯亚贝巴耐多药结核病（DR-TB）治疗启动中心接受治疗的耐多药结核病患者的贫血严重程度及相关因素。
一项回顾性横断面研究。
本研究于2022年9月20日至10月15日在亚的斯亚贝巴的阿莱特和圣彼得专科医院进行。
收集了331例耐多药结核病患者的数据。数据录入Epi-Data 4.1，使用SPSS 25版进行数据清理和分析。在满足多重共线性假设后拟合多项逻辑回归模型，并进行拟合优度检验。以正常血红蛋白水平作为参照类别，报告每个结局变量的比值比（OR）及95%置信区间（CI）。P值<0.05的变量被认为具有统计学意义。
在331例患者中，51.4%有基线贫血，其中5.7%、15.7%和29.9%分别患有重度、中度和轻度贫血。城市居民（调整后比值比[AOR]：0.06，95%CI：0.012，0.32）、政府雇员（AOR：0.33，95%CI：0.001，0.79）、私营企业从业者（AOR：0.02，95%CI：0.001，0.27）、营养不良者（AOR：15.72，95%CI：2.46，100.28）、艾滋病毒感染者（AOR：7.28，95%CI：1.627，32.628）以及农民和学生（AOR：0.05，95%CI：0.004，0.58）与重度贫血显著相关。男性患者（AOR：0.31，95%CI：0.11，0.93）、单身患者（AOR：0.19，95%CI：0.04，0.85）、日工（AOR：6.19，95%CI：1.27，30.2）、营养不良者（AOR：
