Huang Cheng, Gao Zhichao, Huang Zhenxia, Xu Junfeng
Department of Colorectal Surgery, First People's Hospital of Xiaoshan District, Hangzhou, 311200, Zhejiang, China.
Department of Neurosurgery, First People's Hospital of Xiaoshan District, Hangzhou, 311200, Zhejiang, China.
Sci Rep. 2025 May 2;15(1):15442. doi: 10.1038/s41598-025-99540-5.
The global rise in obesity and diabetes has been paralleled by a rising incidence of metabolic dysfunction-associated steatotic liver disease (MASLD). Although previous studies have explored the association between body roundness index (BRI) and MASLD, the specific relationship in non-diabetic Japanese adults requires further investigation. This study analyzed data from 15,299 participants enrolled in the NAGALA cohort (2004-2015) to explore the association between BRI and MASLD through multivariable logistic regression, stratified analysis, and restricted cubic spline modeling. The prevalence of MASLD was 14.46%, with 13.73% occurring in non-obese individuals (BMI < 30). After adjusting for all confounding factors, BRI demonstrated a significant association with MASLD, yielding an adjusted odds ratio of 1.72 (95% CI 1.48-1.99). The restricted cubic spline model revealed a nonlinear relationship, with an inflection point at 3.06. Stratified analyses revealed stronger associations in individuals with lower BMI (≤ 24 kg/m).
全球肥胖和糖尿病发病率的上升伴随着代谢功能障碍相关脂肪性肝病（MASLD）发病率的上升。尽管先前的研究已经探讨了体圆度指数（BRI）与MASLD之间的关联，但非糖尿病日本成年人中的具体关系仍需进一步研究。本研究分析了纳入NAGALA队列（2004 - 2015年）的15299名参与者的数据，通过多变量逻辑回归、分层分析和受限立方样条模型来探讨BRI与MASLD之间的关联。MASLD的患病率为14.46%，其中13.73%发生在非肥胖个体（BMI＜30）中。在调整所有混杂因素后，BRI与MASLD表现出显著关联，调整后的优势比为1.72（95%CI 1.48 - 1.99）。受限立方样条模型显示出非线性关系，拐点为3.06。分层分析显示，BMI较低（≤24 kg/m²）的个体中关联更强。
