El Hennawy Hany M, Safar Omar, Faifi Abdullah S Al, El Hennawy Maryam H, Alghamdi Balqees, Ali Amani, Alqahtani Manar, Zaitoun Mohammad F, Alasmari Sharifah A, Serageldeen Ahmed, Fourtounas Konstantinos, Ayyad Mostafa, Ali Ahmed, Zahran Mohamed H
Surgery Department, Section of Transplantation, Armed Forces Hospitals, Khamis Mushayte, Southern Region 101, KSA, Saudi Arabia.
Urology Department, Armed Forces Hospitals, Southern Region, Khamis Mushayte, KSA, Saudi Arabia.
BMC Nephrol. 2025 May 2;26(1):221. doi: 10.1186/s12882-025-04143-x.
Due to a shortage of cadaveric organs for transplantation, some Saudi patients seek to purchase kidneys in other countries. However, kidney transplantation (KT) abroad is often associated with negative outcomes. This study shared the experiences of two Saudi transplantation centers regarding unrelated KT overseas.
This retrospective comparative cohort study included patients who underwent commercial KT abroad (Group I) and local patients who received living unrelated KT between September 2017 and July 2024, with available follow-up for at least one year. The primary outcome was to compare the perioperative outcomes. The secondary outcome was to compare the cumulative graft survival between both groups using cox-regression analysis.
Group I included 96 patients and group II included 108 patients. Group I had a statistically significant longer 30-day hospital stay (9.4 ± 1.6 vs. 7.9 ± 1 days, P < 0.001). Primary functioning graft was significantly lower in Group I (83.3% vs. 93.5%; p = 0.01). Group I was associated with statistically significant higher incidence of surgical site infection (SSI) (P = 0.03), lymphocele (P = 0.007) and UTI (P = 0.002). The 1-, 2-, 3-, and 5-year cumulative graft survivals were 80%, 79%, 74%, and 54%, respectively in group I compared to 98%, 97%, 90%, and 60%, respectively in group II. [HR = 2, 95% CI = 1.1-3.8, P = 0.02] CONCLUSION: Commercial transplantation graft survival rates are lower, and overall outcomes are worse than those of traditional unrelated transplantation in the midterm. Educating patients about the risks associated with overseas KT and promoting public registration for deceased organ donation could help mitigate this practice.
Not applicable.
由于用于移植的尸体器官短缺，一些沙特患者试图在其他国家购买肾脏。然而，在国外进行肾移植（KT）往往会带来负面结果。本研究分享了两个沙特移植中心在海外进行非亲属肾移植的经验。
这项回顾性比较队列研究纳入了在国外接受商业性肾移植的患者（第一组）以及在2017年9月至2024年7月期间接受非亲属活体肾移植且有至少一年可用随访数据的当地患者。主要结局是比较围手术期结局。次要结局是使用cox回归分析比较两组之间的累积移植物存活率。
第一组包括96例患者，第二组包括108例患者。第一组的30天住院时间在统计学上显著更长（9.4±1.6天对7.9±1天，P<0.001）。第一组的原发性功能移植物显著更低（83.3%对93.5%；p = 0.01）。第一组的手术部位感染（SSI）、淋巴囊肿（P = 0.007）和尿路感染（UTI）（P = 0.002）发生率在统计学上显著更高。第一组的1年、2年、3年和5年累积移植物存活率分别为80%、79%、74%和54%，而第二组分别为98%、97%、90%和60%。[风险比（HR）= 2，95%置信区间（CI）= 1.1 - 3.8，P = 0.02] 结论：商业性移植的移植物存活率较低，中期总体结局比传统非亲属移植更差。对患者进行海外肾移植相关风险的教育以及促进公众登记成为已故器官捐赠者有助于减少这种行为。
不适用。
