Alghadeer Sultan M, Alsuwayegh Aseel, AlMuqati Hessa, Alammari Maha A, Almohammed Omar A
Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Pharmaceutical Care Services, King Saud University Medical City, Riyadh, Saudi Arabia.
Ann Med. 2025 Dec;57(1):2496797. doi: 10.1080/07853890.2025.2496797. Epub 2025 May 3.
Despite the essential of understanding patterns of status epilepticus (SE) and investigating appropriate therapy for these patients, such data are limited in the Saudi population.
A retrospective study including adult patients who were admitted to emergency departments (EDs) in two hospitals due to SE was conducted between May 2015 and July 2021. We aimed to describe the characteristics for patients who were admitted to ED with SE, describe the pattern of pharmacotherapy used in these patients, assess patients' response to these pharmacotherapy agents in different stages and investigate reasons for treatment failure.
A total of 420 SE episodes that received at least one dose of benzodiazepines (BDZs) or anti-seizure medications (ASMs) in ED were included. The mean age for them was 38.7 ±19.1 years and 89.0% had a history of epilepsy . BDZs or ASMs were used on first trial in 60.0% and 40.0% of episodes; and 20.6% and 84.5% ( < 0.0001) of these cases responded, respectively. The overall response to BDZs in all trials was 24.8% while it was 79.1% for the ASMs. The issue of under-dosing was more prevalent in BDZs' compared to ASMs trials (63.4% vs. 19.6%) and was significantly associated with lack of response to therapy (86.6% vs. 0.0%; < 0.0001).
There is an immanent need for educational, drug regulation awareness programs, and protocols enforcement policies that aims to optimize patient care by improving physicians' adherence to clinical guidelines' recommendations to improve the status of managing patients with SE in Saudi Arabia.
尽管了解癫痫持续状态（SE）的模式并为这些患者研究合适的治疗方法至关重要，但沙特人群中的此类数据有限。
进行了一项回顾性研究，纳入了2015年5月至2021年7月期间因SE入住两家医院急诊科的成年患者。我们旨在描述因SE入住急诊科患者的特征，描述这些患者使用的药物治疗模式，评估患者在不同阶段对这些药物治疗药物的反应，并调查治疗失败的原因。
共纳入420例在急诊科接受至少一剂苯二氮䓬类药物（BDZs）或抗癫痫药物（ASMs）治疗的SE发作病例。他们的平均年龄为38.7±19.1岁，89.0%有癫痫病史。60.0%和40.0%的发作病例首次试用BDZs或ASMs；这些病例中分别有20.6%和84.5%（<0.0001）有反应。所有试验中对BDZs药物的总体反应率为24.8%，而对ASMs药物为79.1%。与ASMs试验相比（63.4%对19.6%），BDZs药物剂量不足的问题更普遍，并且与治疗无反应显著相关（86.6%对0.0%；<0.0001）。
迫切需要开展教育、提高药物监管意识项目以及执行方案政策，旨在通过提高医生对临床指南建议的依从性来优化患者护理，以改善沙特阿拉伯SE患者的管理状况。
