Harrison Megan, Lawler Chloe, Lake Fiona, Navaratnam Vidya, Fermoyle Caitlin, Moodley Yuben, Corte Tamera J
Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.
Department of Respiratory Medicine, Sir Charles Gairdner Hospital, Nedlands, WA, Australia.
Ther Adv Respir Dis. 2025 Jan-Dec;19:17534666251335774. doi: 10.1177/17534666251335774. Epub 2025 May 3.
The interstitial lung diseases (ILDs) are a heterogeneous and complex group of diseases. The treatable trait (TT) model represents a shift in ILD management, away from traditional diagnostic labels towards a more individualised, trait-focused approach. This review explores the application of the TT paradigm to ILD, identifying key traits across the aetiological, pulmonary, extrapulmonary and behavioural domains. By addressing these traits, the TT model offers a framework to improve outcomes in ILD through multidisciplinary management with a precision medicine focus. Further research is necessary to evaluate the overall impact of this TT model on ILD care.
间质性肺疾病（ILDs）是一组异质性且复杂的疾病。可治疗特征（TT）模型代表了ILD管理方式的转变，从传统的诊断标签转向更个体化、以特征为重点的方法。本综述探讨了TT范式在ILD中的应用，确定了病因、肺部、肺外和行为领域的关键特征。通过解决这些特征，TT模型提供了一个框架，以精准医学为重点，通过多学科管理改善ILD的治疗效果。有必要进行进一步研究以评估该TT模型对ILD护理的总体影响。
