Algren Maria Holst, Timmermann Amalie, Valentiner-Branth Palle, Thygesen Lau Caspar, Tolstrup Janne Schurmann
National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark.
National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark.
Vaccine. 2025 May 22;56:127202. doi: 10.1016/j.vaccine.2025.127202. Epub 2025 May 2.
Human papillomavirus (HPV) is a common sexually transmitted infection. Risky behaviours such as non-condom use, smoking, and binge drinking tend to cluster within the same individuals, increasing their propensity to become infected with HPV. This study aimed to compare risk behaviours, including non-condom use, smoking, and frequent binge drinking, among HPV-vaccinated and unvaccinated young women in Denmark.
Survey data from 14,614 young women aged 15-23 years from the Danish National Youth Study 2019 was used to analyze non-condom use, smoking, and frequent binge drinking. Data on HPV vaccination status was extracted from the Danish Vaccination Register. Associations were assessed using multilevel logistic regression.
In unadjusted analyses, the odds of non-condom use were higher among vaccinated women compared to unvaccinated women (OR: 1.30, 95% CI: 1.09-1.55). Associations were weaker and not statistically significant after adjustment for age. After adjusting for other demographic and socioeconomic factors, smoking, and binge drinking, the odds of non-condom use were 21% higher (95% CI: 1-44%) among vaccinated women than among unvaccinated women. When excluding women in steady relationships using hormonal contraceptives, the association was attenuated and no longer statistically significant. HPV vaccination status was not associated with smoking or binge drinking.
This study showed no clear association between being HPV vaccinated and risk behaviour including, smoking and binge drinking among young women. Non-condom use was more prevalent among the HPV-vaccinated women, but the results suggest that age, relationship status and hormonal contraceptive use may explain a considerable part of the association.
人乳头瘤病毒（HPV）是一种常见的性传播感染。诸如不使用避孕套、吸烟和酗酒等危险行为往往集中在同一人群中，增加了他们感染HPV的可能性。本研究旨在比较丹麦接种和未接种HPV疫苗的年轻女性之间的危险行为，包括不使用避孕套、吸烟和频繁酗酒。
使用丹麦2019年全国青年研究中14614名15至23岁年轻女性的调查数据，分析不使用避孕套、吸烟和频繁酗酒情况。HPV疫苗接种状况的数据从丹麦疫苗接种登记册中提取。使用多水平逻辑回归评估相关性。
在未经调整的分析中，接种疫苗的女性不使用避孕套的几率高于未接种疫苗的女性（比值比：1.30，95%置信区间：1.09 - 1.55）。在对年龄进行调整后，相关性减弱且无统计学意义。在对其他人口统计学和社会经济因素、吸烟和酗酒进行调整后，接种疫苗的女性不使用避孕套的几率比未接种疫苗的女性高21%（95%置信区间：1 - 44%）。当排除使用激素避孕药的稳定关系中的女性时，这种相关性减弱且不再具有统计学意义。HPV疫苗接种状况与吸烟或酗酒无关。
本研究表明，在年轻女性中，接种HPV疫苗与包括吸烟和酗酒在内的危险行为之间没有明显关联。不使用避孕套在接种HPV疫苗的女性中更为普遍，但结果表明年龄、恋爱状况和激素避孕药的使用可能在很大程度上解释了这种关联。
