Barglow P, Hatcher R, Berndt D, Phelps R
J Nerv Ment Dis. 1985 Oct;173(10):615-20. doi: 10.1097/00005053-198510000-00007.
The authors tested the relationship between psychosocial childbearing stress factors and metabolic control in a research sample of 39 pregnant insulin-dependent diabetic women. Subjects were selected using rigorous exclusion criteria from a population of more than 200 pregnant diabetic patients assessed in a University National Institutes of Health Center. Metabolic control was determined by plasma levels of preprandial day, night, and early morning fasting glucose, urinary ketones, and glycosylation of hemoglobin. Differences in plasma glucose concentrations and urinary ketone levels at several times during the day and night were associated with psychosocial stress factors. A similar relationship between stress and levels of diabetic control could not be demonstrated by hemoglobin A1 assay, a result contradicting most prior studies of adolescent populations. These findings are compatible with a biopsychosocial model of diabetes mellitus and emphasize the importance of using several different measures of diabetic control to determine stress-control relationships.
作者在一个由39名怀孕的胰岛素依赖型糖尿病女性组成的研究样本中，测试了心理社会生育压力因素与代谢控制之间的关系。研究对象是从美国国立卫生研究院大学中心评估的200多名怀孕糖尿病患者中，根据严格的排除标准挑选出来的。代谢控制通过日间、夜间和清晨空腹血糖的血浆水平、尿酮以及血红蛋白糖基化来确定。白天和夜间不同时间的血糖浓度和尿酮水平差异与心理社会压力因素有关。通过血红蛋白A1检测未能证明压力与糖尿病控制水平之间存在类似关系，这一结果与大多数先前针对青少年人群的研究相矛盾。这些发现与糖尿病的生物心理社会模型相符，并强调了使用几种不同的糖尿病控制测量方法来确定压力与控制关系的重要性。
