Kafi-de St Hilaire S, Sovilla J Y, Hjorth S, Gaillard J M
J Neural Transm. 1985;62(3-4):209-17. doi: 10.1007/BF01252237.
The effects of subcutaneous administration of the two enantiomers of 3-(3-hydroxyphenyl)-N-n-propylpiperidine (3-PPP), a new dopamine analogue, were studied with regard to their effects on sleep parameters in the rat. The studies with both enantiomers were carried out taking into account their different effects on central dopaminergic receptors. At low doses they act preferentially as autoreceptor agonists; at higher doses the (+)-form is also an agonist while the (-)-form acts as an antagonist at postsynaptic dopamine receptors. The results showed the following: (1) with the high dose of (+)-3-PPP there was no change in REM sleep, but a marked increase in wakefulness; (2) with the high dose of (-)-3-PPP there was a significant increase in REM sleep and in the mean duration of REM episodes; (3) with the low dose of (+)-3-PPP similar results to those described for high-dose (-)-3-PPP were obtained; (4) there was no significant alteration of sleep parameters with the low dose of (-)-3-PPP. The data are discussed in terms of an active role for dopamine in the regulation of REM sleep.
研究了新型多巴胺类似物3-(3-羟基苯基)-N-正丙基哌啶（3-PPP）的两种对映体皮下给药对大鼠睡眠参数的影响。对两种对映体的研究是在考虑它们对中枢多巴胺能受体的不同作用的情况下进行的。低剂量时它们优先作为自受体激动剂起作用；高剂量时，(+)-形式也是一种激动剂，而(-)-形式在突触后多巴胺受体处起拮抗剂作用。结果如下：(1)高剂量的(+)-3-PPP使快速眼动睡眠无变化，但觉醒显著增加；(2)高剂量的(-)-3-PPP使快速眼动睡眠和快速眼动发作的平均持续时间显著增加；(3)低剂量的(+)-3-PPP获得了与高剂量(-)-3-PPP所述相似的结果；(4)低剂量的(-)-3-PPP对睡眠参数无显著改变。从多巴胺在快速眼动睡眠调节中的积极作用方面对数据进行了讨论。
