Suppression of exploratory locomotor activity in the rat by the local application of 3-PPP enantiomers into the nucleus accumbens.

It was found that (-)-3-PPP, 5-160 microgram/side produced a statistically significant suppression of exploratory locomotor activity after application to the nucleus accumbens. The (+)-isomer was about 8 times less potent in suppressing exploratory activity. Except for suppression of the locomotor activity by 160 micrograms of (-)-3-PPP no statistically significant effects were produced by either isomer applied in the neostriatum.