Decoding Ribosome Stress: How NAT10 Influences Pancreatic Acinar Cell Survival and Cancer Development.
作者信息
Bailey-Lundberg Jennifer M
机构信息
Department of Pathology, Microbiology and Immunology, The University of Nebraska Medical Center, Omaha, Nebraska; Fred and Pamela Buffett Cancer Center, The University of Nebraska Medical Center, Omaha, Nebraska.
出版信息
Cell Mol Gastroenterol Hepatol. 2025;19(7):101516. doi: 10.1016/j.jcmgh.2025.101516. Epub 2025 Apr 30.
Abstract
摘要
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Decoding Ribosome Stress: How NAT10 Influences Pancreatic Acinar Cell Survival and Cancer Development.解码核糖体应激：NAT10如何影响胰腺腺泡细胞存活和癌症发展。
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本文引用的文献
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N-acetylcytidine modification of ITGB5 mRNA mediated by NAT10 promotes perineural invasion in pancreatic ductal adenocarcinoma.由NAT10介导的ITGB5 mRNA的N-乙酰胞苷修饰促进胰腺导管腺癌的神经周围浸润。
J Exp Clin Cancer Res. 2025 Mar 22;44(1):103. doi: 10.1186/s13046-025-03362-2.
2
Inhibition of Ribosome Biogenesis In Vivo Causes p53-Dependent Death and p53-Independent Dysfunction.体内核糖体生物合成的抑制导致p53依赖性死亡和p53非依赖性功能障碍。
Cell Mol Gastroenterol Hepatol. 2025;19(7):101496. doi: 10.1016/j.jcmgh.2025.101496. Epub 2025 Mar 11.
3
The role and mechanism of NAT10-mediated ac4C modification in tumor development and progression.NAT10介导的ac4C修饰在肿瘤发生发展中的作用及机制。
MedComm (2020). 2024 Dec 4;5(12):e70026. doi: 10.1002/mco2.70026. eCollection 2024 Dec.
4
NAT10-mediated AXL mRNA N4-acetylcytidine modification promotes pancreatic carcinoma progression.NAT10 介导的 AXL mRNA N4-乙酰胞嘧啶修饰促进胰腺癌进展。
Exp Cell Res. 2023 Jul 15;428(2):113620. doi: 10.1016/j.yexcr.2023.113620. Epub 2023 May 6.
5
Dynamic RNA acetylation revealed by quantitative cross-evolutionary mapping.通过定量的交叉进化图谱揭示动态 RNA 乙酰化。
Nature. 2020 Jul;583(7817):638-643. doi: 10.1038/s41586-020-2418-2. Epub 2020 Jun 17.
6
The Discovery of Ribosome Heterogeneity and Its Implications for Gene Regulation and Organismal Life.核糖体异质性的发现及其对基因调控和生物生命的意义。
Mol Cell. 2018 Aug 2;71(3):364-374. doi: 10.1016/j.molcel.2018.07.018.
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Human NAT10 is an ATP-dependent RNA acetyltransferase responsible for N4-acetylcytidine formation in 18 S ribosomal RNA (rRNA).人类NAT10是一种依赖ATP的RNA乙酰转移酶，负责在18S核糖体RNA（rRNA）中形成N4-乙酰胞苷。
J Biol Chem. 2014 Dec 26;289(52):35724-30. doi: 10.1074/jbc.C114.602698. Epub 2014 Nov 19.
8
The tumor suppressor rpl36 restrains KRAS(G12V)-induced pancreatic cancer.肿瘤抑制因子rpl36可抑制KRAS（G12V）诱导的胰腺癌。
Zebrafish. 2014 Dec;11(6):551-9. doi: 10.1089/zeb.2014.1024.
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Many ribosomal protein mutations are associated with growth impairment and tumor predisposition in zebrafish.许多核糖体蛋白突变与斑马鱼的生长发育受损和肿瘤易感性有关。
Dev Dyn. 2009 Jan;238(1):76-85. doi: 10.1002/dvdy.21815.
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Spontaneous induction of murine pancreatic intraepithelial neoplasia (mPanIN) by acinar cell targeting of oncogenic Kras in adult mice.通过在成年小鼠的腺泡细胞中靶向致癌性Kras自发诱导小鼠胰腺上皮内瘤变（mPanIN）
Proc Natl Acad Sci U S A. 2008 Dec 2;105(48):18913-8. doi: 10.1073/pnas.0810097105. Epub 2008 Nov 21.
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