Torun Işıl Merve, Dalkiliç Hasine Gözde, Toplak Gülcan, Sönmez Murat
Department of Ophthalmology, Medical Health Sciences University, Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey.
Int Ophthalmol. 2025 May 3;45(1):166. doi: 10.1007/s10792-025-03547-w.
To investigate variations in central corneal thickness (CCT), corneal aberrations, and anterior chamber depth througout the follicular and luteal phases of the menstrual cycle in reproductive-age women with regular menstruation using corneal topography and changes in Schlemm's canal (SC) diameter and area using the anterior segment (AS) module of enchanced depth imaging optical coherence tomography (EDI-OCT).
Corneal topography and AS-EDI-OCT of 69 volunteers included in this prospective study were performed between days 1-5 of the cycle for the follicular phase and between days 25-35 for the luteal phase. SC diameter and area calculations were calculated using the ImageJ software.
During the luteal phase, there was a significant increase in CCT and SC diameter and trefoil 0° aberrations compared with the follicular phase. Additionally, a significant positive correlation was obtained between intraocular pressure and SC diameter, and a significant negative correlation between CCT and SC diameter and area.
Changes in corneal and anterior chamber angle were observed due to hormonal changes in the menstrual cycle. This is the first study to investigate the changes in SC diameter and area and corneal aberrations during the menstrual cycle.
利用角膜地形图研究月经周期规律的育龄期女性在月经周期的卵泡期和黄体期中央角膜厚度（CCT）、角膜像差及前房深度的变化，并利用增强深度成像光学相干断层扫描（EDI-OCT）的前段（AS）模块研究施莱姆管（SC）直径和面积的变化。
对纳入本前瞻性研究的69名志愿者在月经周期的第1 - 5天进行卵泡期的角膜地形图和AS-EDI-OCT检查，在第25 - 35天进行黄体期的检查。使用ImageJ软件计算SC直径和面积。
与卵泡期相比，黄体期CCT、SC直径和三叶形0°像差显著增加。此外，眼内压与SC直径之间存在显著正相关，CCT与SC直径和面积之间存在显著负相关。
观察到月经周期中激素变化导致角膜和前房角的改变。这是第一项研究月经周期中SC直径和面积以及角膜像差变化的研究。
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