Islam Sabrina, Liden Tiffany, Goff Roman, Schug Kevin A
Department of Chemistry and Biochemistry, The University of Texas at Arlington, 700 Planetarium Place, Arlington, TX 76019, USA.
Shimadzu Scientific Instruments, Inc., 7102 Riverwood Dr., Columbia, MD 21046, USA.
J Chromatogr A. 2025 Jul 19;1753:466009. doi: 10.1016/j.chroma.2025.466009. Epub 2025 Apr 29.
Psilocybin mushrooms, particularly those containing the psychoactive compounds psilocybin and psilocin, have attracted recent attention due to their potential therapeutic use for the treatment of psychological disorders. To use psilocybin mushrooms in a clinical context, it is important to understand their chemical composition more fully. An untargeted analysis using liquid chromatography (LC) quadrupole time-of-flight mass spectrometry was performed to explore the chemical diversity of various species of psilocybin mushrooms (PM) relative to edible non-psilocybin mushrooms (NPM). The analysis was performed using reversed phase LC with electrospray ionization in data independent acquisition mode. The study revealed the presence of several classes of compounds and their derivatives. The data was analyzed using multiple statistical methods. Principal component analysis showed that the psilocybin mushrooms and non-psilocybin mushrooms are compositionally very different from each other. These findings contribute to a deeper understanding of the chemical complexity of psilocybin mushrooms and lay groundwork for future research into their potential applications in medicine and psychology.
裸盖菇，尤其是那些含有精神活性化合物裸盖菇素和脱磷酸裸盖菇素的裸盖菇，因其在治疗心理障碍方面的潜在治疗用途而受到了近期的关注。要在临床环境中使用裸盖菇，更全面地了解它们的化学成分很重要。进行了一项使用液相色谱（LC）四极杆飞行时间质谱的非靶向分析，以探究各种裸盖菇（PM）相对于可食用的非裸盖菇（NPM）的化学多样性。该分析使用反相液相色谱和电喷雾电离，以数据独立采集模式进行。研究揭示了几类化合物及其衍生物的存在。使用多种统计方法对数据进行了分析。主成分分析表明，裸盖菇和非裸盖菇在成分上彼此非常不同。这些发现有助于更深入地了解裸盖菇的化学复杂性，并为未来研究它们在医学和心理学中的潜在应用奠定基础。
