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一种定量分析碘-123放射性药物中碘-124污染的简单方法。

A simple method to quantitate iodine-124 contamination in iodine-123 radiopharmaceuticals.

作者信息

Palmer D W, Rao S A

出版信息

J Nucl Med. 1985 Aug;26(8):936-40.

PMID:4032037
Abstract

Iodine-123 (123I) produced by the 124Te(p,2n)123I reaction contains several percent 124I radionuclidic contamination at the time of imaging. Since 124I degrades the quality of the images and causes unnecessary radiation absorbed dose to the patient, it is important to know the amount present in radiopharmaceuticals at the time of administration. A simple approach is described which uses a radionuclide dose calibrator and lead shield. The sample is assayed both shielded and unshielded and the ratio of readings depends uniquely upon the percent 124I present. The technique can be adopted for any type of dose calibrator, sample container, and Pb shield, but use of the numeric constants reported here should be restricted to the specified equipment.

摘要

通过124Te(p,2n)123I反应产生的碘-123(123I)在成像时含有百分之几的124I放射性核素污染。由于124I会降低图像质量并给患者带来不必要的辐射吸收剂量,因此了解给药时放射性药物中124I的含量很重要。本文描述了一种使用放射性核素剂量校准器和铅屏蔽的简单方法。对样品进行屏蔽和非屏蔽测量,读数之比仅取决于124I的百分比含量。该技术可用于任何类型的剂量校准器、样品容器和铅屏蔽,但此处报告的数值常数仅适用于指定的设备。

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A simple method to quantitate iodine-124 contamination in iodine-123 radiopharmaceuticals.一种定量分析碘-123放射性药物中碘-124污染的简单方法。
J Nucl Med. 1985 Aug;26(8):936-40.
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