Wang Jin, Zha Xiaoliang, Zhang Qiu, Chen Moru, Zhang He, Ding Feng, Zeng Jianfeng, Ren Tantan, Chen Ye, Lu Shuihua, Liu Xiangxiang
Shenzhen Third People's Hospital, the Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen, 518112, China.
Shenzhen Second People's Hospital, the First Affiliated Hospital of Shenzhen University, Shenzhen, 518035, China.
BMC Infect Dis. 2025 May 4;25(1):651. doi: 10.1186/s12879-025-11026-x.
The study aimed to assess the willingness of receiving tuberculosis preventive treatment (TPT) and identify influence factors on their decisions among individuals with latent tuberculosis infection (LTBI).
Individuals diagnosed with LTBI at a designated tuberculosis (TB) hospital were recruited from July 2023 to June 2024. Data on socio-demographic characteristics, knowledge of TB, the decision to receive TPT along with the underlying reasons were collected using electronic questionnaires. Binary logistic regression analysis was employed to identify independent factors associated with the willingness of receiving TPT. A P value less than 0.05 was considered statistically significant.
A total of 317 individuals with LTBI were included in this study. Among them, 254 (80.13%) expressed a willingness to receive TPT, while 63 declined. Of those 254, 58 (22.83%) ultimately refused treatment. Gender (P < 0.05; OR = 1.983; 95% CI:1.052-3.738), educational level (P < 0.01; OR = 3.489; 95% CI:1.524-7.985) and knowledge of TB (P < 0.05; OR = 3.688; 95% CI:1.835-16.278) were significantly associated with willingness to receive TPT. The top three reasons for willingness to receive TPT were: concern about developing active tuberculosis (ATB), reducing the risk and severity of ATB, and doctor's recommendation, accounting for 69.09%, 46.69%, and 42.90%, respectively. The top four reasons for refusal TPT included: fear of adverse drug reactions, perceived low risk of developing ATB, fear of adverse drug events and uncertainty about the effectiveness of TPT, accounting for 9.46%, 6.94%, 4.73%, and 4.73%, respectively.
TPT acceptance remained suboptimal and was influenced by gender, education level and TB knowledge. Improving LTBI patient and health care provider education on TB risks and TPT benefits could enhance adherence.
Not applicable.
本研究旨在评估潜伏性结核感染（LTBI）个体接受结核病预防性治疗（TPT）的意愿，并确定影响其决策的因素。
2023年7月至2024年6月，在一家指定的结核病医院招募被诊断为LTBI的个体。使用电子问卷收集社会人口学特征、结核病知识、接受TPT的决定及其潜在原因的数据。采用二元逻辑回归分析确定与接受TPT意愿相关的独立因素。P值小于0.05被认为具有统计学意义。
本研究共纳入317例LTBI个体。其中，254例（80.13%）表示愿意接受TPT，63例拒绝。在这254例中，58例（22.83%）最终拒绝治疗。性别（P＜0.05；OR = 1.983；95%CI：1.052 - 3.738）、教育水平（P＜0.01；OR = 3.489；95%CI：1.524 - 7.985）和结核病知识（P＜0.05；OR = 3.688；95%CI：1.835 - 16.278）与接受TPT的意愿显著相关。愿意接受TPT的前三个原因是：担心发展为活动性结核病（ATB）、降低ATB的风险和严重程度以及医生的建议，分别占69.09%、46.69%和42.90%。拒绝TPT的前四个原因包括：害怕药物不良反应、认为发展为ATB的风险低、害怕药物不良事件以及对TPT有效性的不确定性，分别占9.46%、6.94%、4.73%和4.73%。
TPT的接受率仍不理想，且受性别、教育水平和结核病知识的影响。提高LTBI患者和医疗服务提供者对结核病风险和TPT益处的认识可能会提高依从性。
不适用。
