中国结核病预防性治疗接受度的障碍：一项多中心横断面研究

Barriers to the Acceptance of Tuberculosis Preventive Treatment: A Multicenter Cross-sectional Study in China.

作者信息

Ren Jingjuan, Huang Fei, Chen Haifeng, Zhang Huimin, Sun Jianwei, Zhao Ahui, Xu Zuhui, Liu Liqin, Wu Huizhong, Fang Lanjun, Wu Chengguo, Wang Qingya, Zhang Wenqian, Sun Xinhua, Liu Xiaoping, Yuan Jizheng, Chen Bohan, Wang Ni, Zhao Yanlin

机构信息

National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, Chinese Center for Disease Control and Prevention, Beijing 102206, China;National Center for Tuberculosis Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.

Hebei Province Center for Disease Prevention and Control, Hebei 050021, China.

出版信息

Biomed Environ Sci. 2024 Nov 20;37(11):1303-1309. doi: 10.3967/bes2024.150.

DOI:10.3967/bes2024.150

PMID:39667967

Abstract

OBJECTIVE

We aimed to understand the willingness and barriers to the acceptance of tuberculosis (TB) preventive treatment (TPT) among people with latent TB infection (LTBI) in China.

METHODS

A multicenter cross-sectional study was conducted from May 18, 2023 to December 31, 2023 across 10 counties in China. According to a national technical guide, we included healthcare workers, students, teachers, and others occupations aged 15-65 years as our research participants.

RESULTS

Overall, 17.0% (183/1,077) of participants accepted TPT. There were statistically significant differences in the acceptance rate of TPT among different sexes, ages, educational levels, and occupations ( < 0.05). The main barriers to TPT acceptance were misconceptions that it had uncertain effects on prevention (57.8%, 517/894), and concerns about side effects (32.7%, 292/894).

CONCLUSION

An enhanced and comprehensive understanding of LTBI and TPT among people with LTBI is vital to further expand TPT in China. Moreover, targeted policies need to be developed to address barriers faced by different groups of people.

摘要