Ren Jingjuan, Huang Fei, Chen Haifeng, Zhang Huimin, Sun Jianwei, Zhao Ahui, Xu Zuhui, Liu Liqin, Wu Huizhong, Fang Lanjun, Wu Chengguo, Wang Qingya, Zhang Wenqian, Sun Xinhua, Liu Xiaoping, Yuan Jizheng, Chen Bohan, Wang Ni, Zhao Yanlin
National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, Chinese Center for Disease Control and Prevention, Beijing 102206, China;National Center for Tuberculosis Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
Hebei Province Center for Disease Prevention and Control, Hebei 050021, China.
Biomed Environ Sci. 2024 Nov 20;37(11):1303-1309. doi: 10.3967/bes2024.150.
We aimed to understand the willingness and barriers to the acceptance of tuberculosis (TB) preventive treatment (TPT) among people with latent TB infection (LTBI) in China.
A multicenter cross-sectional study was conducted from May 18, 2023 to December 31, 2023 across 10 counties in China. According to a national technical guide, we included healthcare workers, students, teachers, and others occupations aged 15-65 years as our research participants.
Overall, 17.0% (183/1,077) of participants accepted TPT. There were statistically significant differences in the acceptance rate of TPT among different sexes, ages, educational levels, and occupations ( < 0.05). The main barriers to TPT acceptance were misconceptions that it had uncertain effects on prevention (57.8%, 517/894), and concerns about side effects (32.7%, 292/894).
An enhanced and comprehensive understanding of LTBI and TPT among people with LTBI is vital to further expand TPT in China. Moreover, targeted policies need to be developed to address barriers faced by different groups of people.
我们旨在了解中国潜伏性结核感染（LTBI）人群接受结核病（TB）预防性治疗（TPT）的意愿和障碍。
2023年5月18日至2023年12月31日在中国10个县开展了一项多中心横断面研究。根据国家技术指南，我们纳入了年龄在15 - 65岁的医护人员、学生、教师及其他职业人群作为研究参与者。
总体而言，17.0%（183/1077）的参与者接受了TPT。不同性别、年龄、教育水平和职业的TPT接受率存在统计学显著差异（<0.05）。接受TPT的主要障碍是认为其预防效果不确定的误解（57.8%，517/894）以及对副作用的担忧（32.7%，292/894）。
增强LTBI人群对LTBI和TPT的全面了解对于在中国进一步扩大TPT至关重要。此外，需要制定针对性政策以解决不同人群面临的障碍。
