Suzuki M, Sato A
J Nutr Sci Vitaminol (Tokyo). 1985 Apr;31(2):209-23. doi: 10.3177/jnsv.31.209.
Digestibility of alpha- and beta-cyclodextrin (CD) and nutritional consequences of alpha-CD and a CD mixture (n-dextrin, alpha-, beta-and gamma-CDs = 50, 30, 15 and 5% by weight) were investigated in rats. In contrast with beta-CD, alpha-CD was revealed to be indigestible. Growing rats were fed on diets supplemented with the CD mixture at 19.5, 39, 58.5 and 78% levels for 110 days, resulting in smaller weight gain and body fat deposition when they were fed on a higher CD diet. Rates of weight loss during the restricted feeding were faster in rats fed on a higher CD diet. These were due to food efficiency lowered by CD. Reduced serum and liver triacylglycerol (TG) levels were noted during a 110-day period of feeding of the CD diets, and the former was revealed due to a reduced hepatic-intestinal TG secretion rate. Rats fed on a 78% CD diet, which contained alpha-CD at the 24% level, showed abnormal symptoms such as poor appetite and constipation with gas accumulation in the large intestine, and some of them died during the first 2-week feeding period. However, the surviving animals showed adaptation to the diet in the later period of the 110-day feeding. These results suggest that alpha-CD may be classified as dietary fiber which can modulate lipid metabolism in rats. Furthermore, the CD mixture may be available as a calorie substitute for weight control, which may owe mostly to alpha-CD.
在大鼠中研究了α-和β-环糊精（CD）的消化率以及α-环糊精和一种环糊精混合物（n-糊精，α-、β-和γ-环糊精，重量比为50%、30%、15%和5%）的营养后果。与β-环糊精不同，α-环糊精被发现是不可消化的。将生长中的大鼠喂食添加了19.5%、39%、58.5%和78%水平环糊精混合物的饲料，持续110天，结果发现当它们食用较高环糊精含量的饲料时，体重增加和体脂肪沉积较少。在限食期间，食用较高环糊精含量饲料的大鼠体重减轻速度更快。这些是由于环糊精降低了食物效率。在喂食环糊精饲料的110天期间，血清和肝脏三酰甘油（TG）水平降低，前者是由于肝肠TG分泌率降低所致。喂食含24%水平α-环糊精的78%环糊精饲料的大鼠出现异常症状，如食欲不振和便秘，大肠内有气体积聚，其中一些在最初的2周喂食期内死亡。然而，存活的动物在110天喂食期的后期表现出对该饲料的适应性。这些结果表明，α-环糊精可归类为膳食纤维，能够调节大鼠的脂质代谢。此外，环糊精混合物可作为控制体重的热量替代品，这可能主要归功于α-环糊精。
