Liu Fuquan, Hao Shuai, Wang Jingliyu, Chen Lei, Jiang Ning, Liu Laixing, Wang Xiangyi
Department of Neurosurgery, Mental Health Institute of Inner Mongolia Autonomous Region, The Third Hospital of Inner Mongolia Autonomous Region, Hohhot, China.
Department of Neurosurgery, Inner Mongolia Baogang Hospital, Baotou, China.
Brain Behav. 2025 May;15(5):e70500. doi: 10.1002/brb3.70500.
Intracranial aneurysm (IA) is characterized by localized dilation or ballooning of a blood vessel in the brain with life-threatening consequences. This study set out to investigate the value of Long noncoding RNA myocardial infarction associated transcript (LncRNA MIAT) in diagnosis, rupture prediction, and prognosis for IA patients.
The clinical characteristics of controls (100 cases) and IA patients, including 88 cases of ruptured IA (RIA) and 132 cases of unruptured IA (UIA), were analyzed using the chi-square test and t-test. MIAT expression in the serum was detected. The diagnostic efficacy of MIAT for IA was assessed through receiver operating characteristic (ROC) curve analysis. IA patients were categorized into low-expression and high-expression groups, and the correlation between MIAT expression and clinical indicators in IA patients was analyzed. The risk factors for IA rupture were analyzed. The correlation between MIAT expression and the overall survival of IA patients was assayed. The risk factors for poor prognosis in IA patients were analyzed.
LncRNA MIAT was elevated in IA patients, with higher expression in RIA patients than in UIA patients. MIAT expression could distinguish between healthy control and IA patients (area under the curve, AUC = 0.794, cut-off value = 1.26, sensitivity = 68.64%, specificity = 83.00%, p < 0.001), healthy control and UIA patients (AUC = 0.782, cut-off value = 1.15, sensitivity = 75.76%, specificity = 68.00%, p < 0.001), and UIA patients and RIA patients (AUC = 0.690, cut-off value = 1.46, sensitivity = 76.14%, specificity = 68.94%, p < 0.001). MIAT expression was significantly associated with hypertension, IA location, and IA rupture status. MIAT was an independent risk factor for IA rupture. For every one-unit increase in the relative expression of MIAT, the risk of poor prognosis in IA patients increased by 2.415 times (p = 0.014, 95% CI: 1.192-4.890). MIAT expression was correlated with the overall survival of IA patients and IA rupture in UIA patients. MIAT was an independent risk factor for poor prognosis of IA patients. For every one-unit increase in the relative expression of MIAT, the risk of poor prognosis in IA patients increased by 2.415 times (p = 0.014, 95% CI: 1.192-4.890).
Highly expressed MIAT is an independent risk factor for poor prognosis of IA and can support IA diagnosis and rupture prediction.
颅内动脉瘤（IA）的特征是脑血管局部扩张或呈气球样膨出，可危及生命。本研究旨在探讨长链非编码RNA心肌梗死相关转录本（LncRNA MIAT）在IA患者诊断、破裂预测及预后评估中的价值。
采用卡方检验和t检验分析100例对照者及IA患者（包括88例破裂性IA，RIA；132例未破裂性IA，UIA）的临床特征。检测血清中MIAT的表达。通过受试者工作特征（ROC）曲线分析评估MIAT对IA的诊断效能。将IA患者分为低表达组和高表达组，分析IA患者中MIAT表达与临床指标的相关性。分析IA破裂的危险因素。测定MIAT表达与IA患者总生存的相关性。分析IA患者预后不良的危险因素。
IA患者中LncRNA MIAT升高，RIA患者中的表达高于UIA患者。MIAT表达可区分健康对照与IA患者（曲线下面积，AUC = 0.794，截断值 = 1.26，灵敏度 = 68.64%，特异度 = 83.00%，p < 0.001）、健康对照与UIA患者（AUC = 0.782，截断值 = 1.15，灵敏度 = 75.76%，特异度 = 68.00%，p < 0.001）以及UIA患者与RIA患者（AUC = 0.690，截断值 = 1.46，灵敏度 = 76.14%，特异度 = 68.94%，p < 0.001）。MIAT表达与高血压、IA位置及IA破裂状态显著相关。MIAT是IA破裂的独立危险因素。MIAT相对表达每增加1个单位，IA患者预后不良的风险增加2.415倍（p = 0.014，95%可信区间：1.192 - 4.890）。MIAT表达与IA患者的总生存及UIA患者的IA破裂相关。MIAT是IA患者预后不良的独立危险因素。MIAT相对表达每增加1个单位，IA患者预后不良的风险增加2.415倍（p = 0.014，95%可信区间：1.192 - 4.890）。
高表达的MIAT是IA患者预后不良的独立危险因素，可辅助IA诊断及破裂预测。
