全球血清阳性率的出生队列和特定年龄趋势：一项范围综述。
Birth cohort and age-specific trends in global seroprevalence: a scoping review.
作者信息
Taylor Chelsea S, McMahon Mercedes V, Ward Zachary J, Alarid-Escudero Fernando, Camargo M Constanza, Laszkowska Monika, Roa Jorge, Yeh Jennifer M
机构信息
Division of General Pediatrics, Boston Children's Hospital, Boston, MA, USA.
Center for Health Decision Science, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
出版信息
Lancet Reg Health Am. 2024 Aug 29;41:100877. doi: 10.1016/j.lana.2024.100877. eCollection 2025 Jan.
UNLABELLED
Gastric cancer persists around the world as one of the leading causes of cancer-related death, despite declines in recent years. The declining prevalence of , the primary risk factor for gastric cancer, has contributed to this reduction and understanding changes in seroprevalence trends over time may yield further insight into gastric cancer incidence trends. We conducted a scoping review to compile data on seroprevalence in asymptomatic populations to assess global trends by age and birth cohort. We found that published data suggest seroprevalence declined among recent birth cohorts and increased with age, with trends differing between regions and sub-regions subject to data availability. The Americas lacked sufficient data to enable more robust assessment of trends by both age and birth cohort.
FUNDING
NCI: U01CA265729, P30 CA008748; NIDDK: K08 DK125876.
未标注
尽管近年来胃癌发病率有所下降，但它仍是全球癌症相关死亡的主要原因之一。胃癌的主要危险因素——幽门螺杆菌感染率的下降促成了这种减少，了解血清流行率随时间的变化趋势可能会进一步洞察胃癌发病率趋势。我们进行了一项范围综述，以收集无症状人群中幽门螺杆菌血清流行率的数据，按年龄和出生队列评估全球趋势。我们发现，已发表的数据表明，在最近出生的队列中幽门螺杆菌血清流行率有所下降，且随年龄增长而上升，不同地区和次区域的趋势因数据可得性而异。美洲缺乏足够的数据来对年龄和出生队列的幽门螺杆菌趋势进行更有力的评估。
资助
美国国立癌症研究所：U01CA265729、P30 CA008748；美国国立糖尿病、消化和肾脏疾病研究所：K08 DK125876。
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